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Bilateral widespread mechanical pain sensitivity in carpal tunnel syndrome: evidence of central processing in unilateral neuropathy.

dc.contributor.authorFernandez de las Peñas, Cesar
dc.contributor.authorDe la llave Rincon, Ana Isabel
dc.contributor.authorFernandez Carnero, Josue
dc.contributor.authorCuadrado, Maria Luz
dc.contributor.authorArendt-Nielsen, Lars
dc.contributor.authorPareja, Juan Antonio
dc.date.accessioned2014-11-07T09:59:23Z
dc.date.available2014-11-07T09:59:23Z
dc.date.issued2009-03
dc.identifier.citationBrain. 2009 Jun;132(Pt 6):1472-9.es
dc.identifier.urihttp://hdl.handle.net/10115/12590
dc.description.abstractThe aim of this study was to investigate whether bilateral widespread pressure hypersensitivity exists in patients with unilateral carpal tunnel syndrome. A total of 20 females with carpal tunnel syndrome (aged 22-60 years), and 20 healthy matched females (aged 21-60 years old) were recruited. Pressure pain thresholds were assessed bilaterally over median, ulnar, and radial nerve trunks, the C5-C6 zygapophyseal joint, the carpal tunnel and the tibialis anterior muscle in a blinded design. The results showed that pressure pain threshold levels were significantly decreased bilaterally over the median, ulnar, and radial nerve trunks, the carpal tunnel, the C5-C6 zygapophyseal joint, and the tibialis anterior muscle in patients with unilateral carpal tunnel syndrome as compared to healthy controls (all, P < 0.001). Pressure pain threshold was negatively correlated to both hand pain intensity and duration of symptoms (all, P < 0.001). Our findings revealed bilateral widespread pressure hypersensitivity in subjects with carpal tunnel syndrome, which suggest that widespread central sensitization is involved in patients with unilateral carpal tunnel syndrome. The generalized decrease in pressure pain thresholds associated with pain intensity and duration of symptoms supports a role of the peripheral drive to initiate and maintain central sensitization. Nevertheless, both central and peripheral sensitization mechanisms are probably involved at the same time in carpal tunnel syndrome.es
dc.language.isoenges
dc.publisherBraines
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectPaines
dc.subjectSensitizationes
dc.subjectCarpal tunnel syndromees
dc.titleBilateral widespread mechanical pain sensitivity in carpal tunnel syndrome: evidence of central processing in unilateral neuropathy.es
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.1093/brain/awp050es
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.subject.unesco3207.11 Neuropatologíaes
dc.description.departamentoFisioterapia, Terapia Ocupacional, Rehabilitación y Medicina Física


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Atribución-NoComercial-SinDerivadas 3.0 EspañaExcept where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España