Expression of immunoregulatory molecules in oral squamous cell carcinoma microenvironment
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2021
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Universidad Rey Juan Carlos
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Resumen
Oral squamous cell carcinoma (OSCC) is the most frequent neoplasm among head and
neck carcinomas, this group is one of the most frequent groups of cancers globally. The
morbidity of its treatment is very high, as is mortality, and the survival of patients with
this disease at five years is approximately 60%. Unfortunately, the average survival of
patients with recurrence of the disease or metastasis is approximately 8-10 months.
The histopathological characteristics of OSCC have been studied, and a histologic risk
assessment system has been developed, motivated by the high rate of relapses of this
neoplasia. Despite that there are studies on the microenvironment in head and neck
cancer, the tumour microenvironment that exists around OSCCs has not yet been studied
in depth, which would improve the understanding of this tumour in the face of the
emergence of immunotherapy since clinical trials conducted in recent years have
evaluated drugs whose therapeutic targets are various immunological checkpoints.
Descripción
Tesis Doctoral leída en la Universidad Rey Juan Carlos de Madrid en 2021. Directores de la Tesis: José Ernesto Moro Rodríguez, José Juan Pozo Kreilinger, José Luís Cebrián Carretero y Custodia García Jiménez
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