Díaz Brage, PabloFogelson, Noa2024-12-262024-12-262021-07-02Fogelson N, Diaz-Brage P. Altered directed connectivity during processing of implicit versus explicit predictive stimuli in Parkinson's disease patients. Brain Cogn. 2021 Aug;152:105773. doi: 10.1016/j.bandc.2021.105773. Epub 2021 Jul 2. PMID: 34225173.0278-2626https://hdl.handle.net/10115/46797This work was supported by grants from the Spanish Ministry of Science and Innovation (PID2019-105645RB-I00), and the Ramón y Cajal national fellowship program to N.F.The study investigated the role of top-down versus bottom-up connectivity, during the processing of implicit or explicit predictive information, in Parkinson's disease (PD). EEG was recorded during the performance of a task, which evaluated the ability to utilize either implicit or explicit predictive contextual information in order to facilitate the detection of predictable versus random targets. Thus, subjects performed an implicit and explicit session, where subjects were either unaware or made aware of a predictive sequence that signals the presentation of a subsequent target, respectively. We evaluated EEG event-related directed connectivity, in PD patients compared with healthy age-matched controls, using phase transfer entropy. PD patients showed increased top-down frontal-parietal connectivity, compared to control subjects, during the processing of the last (most informative) stimulus of the predictive sequence and of random standards, in the implicit and explicit session, respectively. These findings suggest that PD is associated with compensatory top-down connectivity, specifically during the processing of implicit predictive stimuli. During the explicit session, PD patients seem to allocate more attentional resources to non-informative standard stimuli, compared to controls. These connectivity changes shed further light on the cognitive deficits, associated with the processing of predictive contextual information, that are observed in PD patients.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Directed connectivityEEGParkinson’s diseasePhase transfer entropyPredictionArticle10.1016/j.bandc.2021.105773info:eu-repo/semantics/openAccess