Trevissón-Redondo, BibianaBecerro-de-Bengoa-Vallejo, RicardoSevillano, DavidGonzález, NataliaLosa-Iglesias, Marta ElenaLopez-Lopez, DanielAlou, Luis2024-10-252024-10-252022Trevissón B, Becerro-de-Bengoa-Vallejo R, Sevillano D, González N, Losa-Iglesias ME, López-López D, Alou L. Influence of Sexual Dimorphism, Aging, and Differential Cell Capture Efficiency of Blood Separation Systems on the Quality of Platelet-Rich Plasma. J Clin Med. 2022 Mar 18;11(6):1683. doi: 10.3390/jcm11061683. PMID: 35330008; PMCID: PMC8953315.https://hdl.handle.net/10115/40649Few studies have checked the impact of the hormonal/immunological dimorphism of patients on the cellular composition of platelet-rich plasma products (PRP). Whole blood (WB) from 26 volunteers was concentrated using a device previously characterized. Platelet and white blood cell (WBC) counts in WB and PRP were compared between genders, and after the population was split into pre (≤50 years)- and post (>50 years)-menopausal ages. In WB, platelet−total WBC densities were comparable in men and women. The phagocytic cell composition differed (p ≤ 0.04). After dividing by ages, phagocytic cell discrepancies were linked to women > 50 years (p ≤ 0.05), and differences emerged in lymphocyte counts (lower in >50 years groups, within and between genders, p ≤ 0.05). In PRP, densities were significantly higher, but the PRP/WB ratios varied according to blood cell (lower for phagocytic cells) and between subjects (more favorable at a lower density of a particular blood cell in WB). This “system compensatory efficiency” rengAttribution 4.0 Internationalhttps://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/article10.3390/jcm11061683info:eu-repo/semantics/openAccess