Access to 2-substituted 1-pyridin-3-yl-β-carboline derivatives by intramolecular radical cyclization-ring opening-SNAr substitution

Recio, JavierPerez-Redondo, AdrianAlvarez-Builla, JulioBurgos, Carolina2024-02-012024-02-012019-08-08Org. Chem. Front., 2019,6, 3300-33042052-4129https://hdl.handle.net/10115/29438A new method for the synthesis of 1-pyridin-3-yl-β-carboline derivatives involving an intramolecular radical reaction in the presence of tris(trimethylsilyl)silane and azobisisobutyronitrile (TTMSS/AIBN), via a sultam intermediate, which proceeds as a one-pot process by ring opening and SNAr substitution, is described.engBeta-carboline derivativesHarmine derivativesIndolesPyridinium arylationRadicalic CouplingAccess to 2-substituted 1-pyridin-3-yl-β-carboline derivatives by intramolecular radical cyclization-ring opening-SNAr substitutioninfo:eu-repo/semantics/article10.1039/C9QO00944Binfo:eu-repo/semantics/restrictedAccess