González-Gómez, LorenaGañán, JudithMorante-Zarcero, SoniaPérez-Quintanilla, DamiánSierra, Isabel2022-06-102022-06-102022González-Gómez, L.; Gañán, J.; Morante-Zarcero, S.; Pérez-Quintanilla, D.; Sierra, I. Mesostructured Silicas as Cation-Exchange Sorbents in Packed or Dispersive Solid Phase Extraction for the Determination of Tropane Alkaloids in Culinary Aromatics Herbs by HPLC-MS/MS. Toxins 2022, 14, 218. https://doi.org/10.3390/toxins140302182072-6651http://hdl.handle.net/10115/19511In this work, Hexagonal Mesoporous Silica (HMS) and Santa Barbara Amorphous-15 (SBA-15) mesostructured silicas were synthesized and functionalized with sulfonic acid groups. The materials (HMS-SO3 �� and SBA-15-SO3 ��) were evaluated as strong cation exchange sorbents for sample extract clean-up, by solid phase extraction (SPE) and dispersive solid phase extraction, to determine atropine (At) and scopolamine (Sc) in commercial culinary aromatic herbs. Under optimized conditions, 0.25 g of sample was subject to solid–liquid extraction with acidified water (pH 1.0), and good recovery percentages were achieved for At and Sc using 75 mg of HMS-SO3 �� in SPE as the clean-up stage, prior to their determination by HPLC-MS/MS. The proposed method was validated in a thyme sample showing recoveries in the range of 70–92%, good linearity (R2 > 0.999), adequate precision (RSD 14%) and low limits (MDL 0.8–2.2 g/kg and MQL 2.6–7.2 g/kg for both analytes). Sixteen aromatic herbs samples (dried thyme, basil and coriander leaves) were analysed and At was found in fourteen samples over an interval of <5–42 g/kg, whereas Sc was found in three of the sixteen samples studied (between <5–34 g/kg). The amount of At and Sc found in some analysed samples confirms the importance of setting maximum levels of At and Sc in culinary aromatic herbs.engAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/tropane alkaloidssolid-phase extractiondispersive solid-phase extractionstrong cation exchangemesostructured silicasculinary aromatic herbsinfo:eu-repo/semantics/article10.3390/toxins14030218info:eu-repo/semantics/openAccess