Fernández-Hernán, Juan P.López, Antonio J.Torres, BelénMartínez-Campos, EnriqueMatykina, EndzheRams, Joaquín2022-04-212022-04-212021Anticorrosion and Cytocompatibility Assessment of Graphene-Doped Hybrid Silica and Plasma Electrolytic Oxidation Coatings for Biomedical Applications Juan P. Fernández-Hernán, Antonio J. López, Belén Torres, Enrique Martínez-Campos, Endzhe Matykina, and Joaquín Rams ACS Biomaterials Science & Engineering 2021 7 (12), 5861-5877 DOI: 10.1021/acsbiomaterials.1c003262373-9878http://hdl.handle.net/10115/19091Magnesium AZ31 alloy substrates were coated with different coatings, including sol−gel silica-reinforced with graphene nanoplatelets, sol−gel silica, plasma electrolytic oxidation (PEO), and combinations of them, to improve cytocompatibility and control the corrosion rate. Electrochemical corrosion tests, as well as hydrogen evolution tests, were carried out using Hanks’ solution as the electrolyte to assess the anticorrosion behavior of the different coating systems in a simulated body fluid. Preliminary cytocompatibility assessment of the different coating systems was carried out by measuring the metabolic activity, deoxyribonucleic acid quantification, and the cell growth of premyoblastic C2C12-GFP cell cultures on the surface of the different coating systems. Anticorrosion behavior and cytocompatibility were improved with the application of the different coating systems. The use of combined PEO + SG and PEO + SG/GNP coatings significantly decreased the degradation of the specimens. The monolayer sol−gel coatings, with and without GNPs, presented the best cytocompatibility improvement.engAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/magnesiumsol−gelplasma electrolytic oxidationGNPcoatingscorrosioncytocompatibilityinfo:eu-repo/semantics/article10.1021/acsbiomaterials.1c00326info:eu-repo/semantics/openAccess