Gómez-Mejía, EstherVicente-Zurdo, DavidRosales-Conrado, NoeliaLeón-González, María Eugenia2024-10-222024-10-222025-01-15Esther Gómez-Mejía, David Vicente-Zurdo, Noelia Rosales-Conrado, María Eugenia León-González, Unlocking the in vitro neuroprotection of sloe residues phenolic extracts by bioanalytical and chemometric strategies, Food Chemistry, Volume 463, Part 2, 2025, 141208, ISSN 0308-8146, https://doi.org/10.1016/j.foodchem.2024.141208.0308-8146 (print)1873-7072 (online)https://hdl.handle.net/10115/40514Wild fruits, particularly the underutilized sloe (Prunus spinosa), are gaining interest as natural antioxidants, with residues from liqueur production being a source of bioactive compounds. This study proposes a sustainable approach for valorizing sloe residues, seeds and skins, by employing an innovative green extraction method. HPLC-ESI-QTOF and spectrophotometric techniques were used to explore the phenolic profile, highlighting the predominance of quercetin, 2,3-dihydroxybenzoic and ferulic acids (9.7–57 μg·g−1). In addition, the presence of Cu, Zn and Ca was confirmed by atomic absorption spectroscopy. Simultaneously, their neuroprotective potential against Alzheimer's disease (AD) was studied by exploring the inhibition of beta-amyloid aggregation and oxidative stress cytoprotection in SH-SY5Y cell line, standing out 1 μg·g−1 and 10 μg·g−1 extracts of sloe skin. Phenolic composition was correlated with bioactivities by means of multivariate analysis. These results contributed to highlight the potential of this bio-residue as a neuroprotective agent against AD in pharmaceutical and nutraceutical industries.engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Alzheimer's diseaseAβ42Chemometric toolsCircular economyIn vitro antioxidantPolyphenolsSloe bio-residuesinfo:eu-repo/semantics/article10.1016/j.foodchem.2024.141208info:eu-repo/semantics/openAccess