González-Amor, MaríaVila-Bedmar, RocioRodrigues-Díez, RaquelMoreno-Carriles, RosaC. Arcones, AlbaCruces-Sande, MartaSalaices, MercedesMayor Jr, FedericoBriones, Ana M.Murga, Cristina2023-12-222023-12-222020-10-04González-Amor, M.; Vila-Bedmar, R.; Rodrigues-Díez, R.; Moreno-Carriles, R.; Arcones, A.C.; Cruces-Sande, M.; Salaices, M.; Mayor, F., Jr.; Briones, A.M.; Murga, C. Myeloid GRK2 Regulates Obesity-Induced Endothelial Dysfunction by Modulating Inflammatory Responses in Perivascular Adipose Tissue. Antioxidants 2020, 9, 953.2076-3921https://hdl.handle.net/10115/27716In this work we describe a potential role for GRK2 in myeloid cells in orchestrating the responses that promote both inflammation and excessive ROS production by NADPH oxidase in PVAT to decrease endothelium-dependent vasodilation.Perivascular adipose tissue (PVAT) is increasingly being regarded as an important endocrine organ that directly impacts vessel function, structure, and contractility in obesity-associated diseases. We uncover here a role for myeloid G protein-coupled receptor kinase 2 (GRK2) in the modulation of PVAT-dependent vasodilation responses.engAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/perivascular adipose tissue (PVAT)G protein-coupled receptor kinase 2 (GRK2)tumor necrosis factor-α (TNFα)NADPH oxidase (Nox)endothelial dysfunctioninfo:eu-repo/semantics/article10.3390/antiox9100953info:eu-repo/semantics/openAccess