Caroline Silveira MartinezAlyne Gourlart EscobarJosé Antonio Uranga-OcioFranck Maciel PeçanhaDalton Valentim VassalloChristopher ExleyMarta MiguelGiulia Alessandra Wiggers2024-04-162024-04-162017-10Martinez, C. S., Escobar, A. G., Uranga-Ocio, J. A., Peçanha, F. M., Vassallo, D. V., Exley, C., Miguel, M., & Wiggers, G. A. (2017). Aluminum exposure for 60days at human dietary levels impairs spermatogenesis and sperm quality in rats. Reproductive Toxicology, 73, 128-141. 10.1016/j.reprotox.2017.08.0080890-6238https://hdl.handle.net/10115/32328Concerns about environmental aluminum (Al) and reproductive health have been raised. We investigatedthe effects of Al exposure at a human relevant dietary level and a high level exposure to Al. Experiment 1(Lower level) rats were treated orally for 60 days: a) controls – ultrapure water; b) aluminum at 1.5 mg/kgbw/day and c) aluminum at 8.3 mg/kg bw/day. Experiment 2 (High level) rats were treated for 42 days:a) controls – ultrapure water; b) aluminum at 100 mg/kg bw/day. Al decreased sperm count, daily spermproduction, sperm motility, normal morphological sperm, impaired testis histology; increased oxidativestress in reproductive organs and inflammation in testis. Our study shows the specific presence of Alin the germinative cells and, that low concentrations of Al in testes (3.35 _g/g) are sufficient to impairspermatogenesis and sperm quality. Our findings provide a better understanding of the reproductivehealth risk of Al.engAttribution-NonCommercial-NoDerivs 4.0 Internationalhttps://creativecommons.org/licenses/by-nc-nd/4.0/metalReproductive adverse effectsSperm qualityinfo:eu-repo/semantics/article10.1016/j.reprotox.2017.08.008info:eu-repo/semantics/embargoedAccess