Navas, FranciscoPerfhal, StefanieGarino, ClaudioSalassa, LucaNovakova, OlgaNavarro-Ranninger, CarmenBednarski, Patrick J.Malina, JaroslavGómez Quiroga, Adoración2024-05-222024-05-222015-07-21Francisco Navas, Stefanie Perfahl, Claudio Garino, Luca Salassa, Olga Novakova, Carmen Navarro-Ranninger, Patrick J. Bednarski, Jaroslav Malina, Adoración G. Quiroga. Journal of Inorganic Biochemistry, 2015, 153, 211-218.0162-0134https://hdl.handle.net/10115/33036Este artículo describe la reactividad de compuestos de Pt(II) con ligandos yoduro frente a modelos de ADN con y en ausencia de luz ultravioleta-visibleTrans diiodido platinum(II) complexes bearing the same as well as different aliphatic amines (mixed-amines) have interesting biological activity; cytotoxicity and interactions with some important biological models have already been demonstrated. Herein we described the interaction of such compounds with ct-DNA, supercoiled and linearized plasmid DNA and 5-GMP. Interestingly, UV irradiation of these compounds results in an increase in reactivity towards DNA and 5-GMP in such model systems. Additionally, the cytotoxicity of the trans-Pt(II) complexes towards human cancer cells is noticeably increased when treatment is combined for 90 min with UVA-irradiation. With this work we provide evidence that trans diiodido compounds can be activated by UVlight over relatively short treatment times.engAttribution-NonCommercial-NoDerivs 4.0 Internationalhttps://creativecommons.org/licenses/by-nc-nd/4.0/Metallodrug photoactivaton, Platinum drugs, DNA interactionsinfo:eu-repo/semantics/article10.1016/j.jinorgbio.2015.07.008info:eu-repo/semantics/OpenAccess