Daza, AlvarWagemakers, AlexandreRajasekar, ShanmuganathanSanjuán, Miguel A. F.2023-11-212023-11-212013-02-01Alvar Daza, Alexandre Wagemakers, Shanmuganathan Rajasekar, Miguel A.F. Sanjuán. Vibrational resonance in a time-delayed genetic toggle switch. Communications in Nonlinear Science and Numerical Simulation, 18, 2013. https://doi.org/10.1016/j.cnsns.2012.07.010https://hdl.handle.net/10115/26257Biological oscillators can respond in a surprising way when they are perturbed by two external periodic forcing signals of very different frequencies. The response of the system to a low-frequency signal can be enhanced or depressed when a high-frequency signal is acting. This is what is known as vibrational resonance (VR). Here we study this phenomenon in a simple time-delayed genetic toggle switch, which is a synthetic gene-regulatory network. We have found out how the low-frequency signal changes the range of the response, while the high-frequency signal influences the amplitude at which the resonance occurs. The delay of the toggle switch has also a strong effect on the resonance since it can also induce autonomous oscillations.Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/article10.1016/j.cnsns.2012.07.010info:eu-repo/semantics/openAccess