Barba, FructuosoRecio, JavierBatanero, Belen2024-02-052024-02-052013-04-03Tetrahedron Letters 54 (2013) 1835–18380040-4039https://hdl.handle.net/10115/29592The reductive amination of several carbonyl compounds (Leuckart reaction) has been performed using Nmethylformamide and microwave technology. Under these conditions, a new mechanism is proposed via the initial formation of an imine, followed by reduction to the amine by ‘in situ’ generated formic acid, and further formylation of the amine. Using this methodology, the formyl derivatives of several secondary amines were obtained in good to excellent yields.engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Reductive aminationLeuckart reactionMicrowave technologyRedox processFormylation of aminesinfo:eu-repo/semantics/article10.1016/j.tetlet.2013.01.097info:eu-repo/semantics/restrictedAccess