López Ruíz, MartaNavas, FranciscoFernández García, PalomaMartínez Erro, SamuelFuentes, María VictoriaGiráldez, isabeICeballos, LauraFerrer Luque, Carmen MaríaRuíz Linares, MatildeMorales, VictoriaSanz, RaúlGarcía Muñoz, Rafael Á.2024-05-212024-05-212022-12-01 Marta López-Ruíz, Francisco Navas, Paloma Fernández-García, Samuel Martínez-Erro, Mª Victoria Fuentes, Isabel Giráldez, Laura Ceballos, Carmen Mª Ferrer-Luque, Matilde Ruíz-Linares, Victoria Morales, Raúl Sanz, Rafael A. García Muñoz. Journal of Nanobiotechnology, 2022, 20, 502-517.1477-3155https://hdl.handle.net/10115/33020Este artículo describe la síntesis y caracterización de nanopartículas silíceas mesoporosas que contienen un derivado del aminoácido L-Arginina, y han sido evaluadas en aplicaciones dentales para la prevención de caries mediante la liberación prolongada de este compuesto.Dental caries is the major biofilm-mediated oral disease in the world. The main treatment to restore caries lesions consists of the use of adhesive resin composites due to their good properties. However, the progressive degradation of the adhesive in the medium term makes possible the proliferation of cariogenic bacteria allowing secondary caries to emerge. In this study, a dental adhesive incorporating a drug delivery system based on L-arginine-containing mesoporous silica nanoparticles (MSNs) was used to release this essential amino acid as a source of basicity to neutralize the harmful acidic conditions that mediate the development of dental secondary caries. The in vitro and bacterial culture experiments proved that L-arginine was released in a sustained way from MSNs and diffused out from the dental adhesive, effectively contributing to the reduction of the bacterial strains Streptococcus mutans and Lactobacillus casei. Furthermore, the mechanical and bonding properties of the dental adhesive did not change significantly after the incorporation of L-arginine-containing MSNs. These results are yielding glimmers of promise for the costeffective prevention of secondary caries.engAttribution 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Dental caries, Dental adhesive, Drug delivery systems, Mesoporous silica nanoparticles, L-arginineinfo:eu-repo/semantics/article10.1186/s12951-022-01714-0info:eu-repo/semantics/openAccess