Candel, Francisco JavierBarreiro, PabloSan Roman, JesúsCarretero, Maria del MarSanz, Juan CarlosPérez-Abeledo, MartaRamos, BelenViñuela-Prieto, Jose ManuelCanora, JesúsMartínez Peromingo, JavierBarba Martín, RaquelZapatero, Antonio2024-10-292024-10-292021-05-04Francisco Javier Candel, Pablo Barreiro, Jesús San Román, María del Mar Carretero, Juan Carlos Sanz, Marta Pérez-Abeledo, Belén Ramos, José Manuel Viñuela-Prieto, Jesús Canora, Francisco Javier Martínez-Peromingo, Raquel Barba, Antonio Zapatero, the investigators of the SeroSOS study, The demography and characteristics of SARS-CoV-2 seropositive residents and staff of nursing homes for older adults in the Community of Madrid: the SeroSOS study, Age and Ageing, Volume 50, Issue 4, July 2021, Pages 1038–1047, https://doi.org/10.1093/ageing/afab096000207290002-0729 (print)1468-2834 (online)https://hdl.handle.net/10115/40823Background: Nursing homes for older adults have concentrated large numbers of severe cases and deaths for coronavirus disease 2019 (COVID-19). Methods: Point seroprevalence study of nursing homes to describe the demography and characteristic of severe acute respiratory syndrome by coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG)-positive residents and staff. Results: Clinical information and blood samples were available for 9,332 residents (mean age 86.7 ± 8.1 years, 76.4% women) and 10,614 staff (mean age 45.6 ± 11.5, 86.2% women). Up to 84.4% of residents had frailty, 84.9% co-morbidity and 69.3% cognitive impairment; 65.2% of workers were health-aides.COVID-19 seroprevalence was 55.4% (95% confidence interval (CI), 54.4-56.4) for older adults and 31.5% (30.6-32.4) for staff. In multivariable analysis, frailty of residents was related with seropositivity (odds ratio (OR): 1.19, P = 0.02). In the case of staff, age > 50 years (2.10, P < 0.001), obesity (1.19, P = 0.01), being a health-aide (1.94, P < 0.001), working in a center with high seroprevalence in residents (3.49, P < 0.001) and contact with external cases of COVID-19 (1.52, P < 0.001) were factors associated with seropositivity. Past symptoms of COVID-19 were good predictors of seropositivity for residents (5.41, P < 0.001) and staff (2.52, P < 0.001). Conclusions: Level of dependency influences risk of COVID-19 among residents. Individual and work factors, contacts outside the nursing home are associated with COVID-19 exposure in staff members. It is key to strengthen control measures to prevent the introduction of COVID-19 into care facilities from the community.engAgeAntibodiesFrailitySars-cov-2Seroepidemiologic studiesNursing home personnelObesitySerological assaysPrevalenceInfectionSevere acute respiratory syndromeCoronavirus disease 2019Health care facilityinfo:eu-repo/semantics/article10.1093/ageing/afab096info:eu-repo/semantics/closedAccess