Díaz-García, DianaDíaz-Sánchez, MiguelÁlvarez-Conde, JavierGómez-Ruiz, Santiago2024-06-272024-06-272024-05-09D. Díaz-García, M. Díaz-Sánchez, J. Álvarez-Conde, S. Gómez-Ruiz, ChemMedChem 2024, e202400172. https://doi.org/10.1002/cmdc.2024001721860-7187 (online)1860-7179 (print)https://hdl.handle.net/10115/35405We would like to thank funding from the research project PID2022-136417NB-I00 financed by MCIU/AEI/10.13039/501100011033/ and “ERDF A way of making Europe”, and from the Research Thematic Network RED2022-134091-T financed by MCIU/AEI/10.13039/501100011033. We would also like to thank Universidad Rey Juan Carlos for the financial support of our research team COMET-NANO with the project M3271Quantum dots (QDs) semiconducting nanomaterials, have garnered attention due to their distinctive properties, including small size, high luminescence, and biocompatibility. In the context of triple-negative breast cancer (TNBC), notorious for its resistance to conventional treatments, QDs exhibit promising potential for enhancing diagnostic imaging and providing targeted therapies. This review underscores recent advancements in the utilization of QDs in imaging techniques, such as fluorescence tomography and magnetic resonance imaging, aiming at the early and precise detection of tumors. Emphasis is placed on the significance of QD design, synthesis and functionalization processes as well as their use in innovative strategies for targeted drug delivery, capitalizing on their ability to selectively deliver therapeutic agents to cancer cells. As the research in this field advances rapidly, this review covers a classification of QDs according to their composition, the characterization techniques than can be used to determine their properties and, subsequently, emphasizes recent findings in the field of TNBC-targeting, highlighting the imperative need to address challenges, like potential toxicity or methodologies standardization. Collectively, the findings explored thus far suggest that QDs could pave the way for early diagnosis and effective therapy of TNBC, representing a significant stride toward precise and personalized strategies in treating TNBCengAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/article10.1002/cmdc.202400172info:eu-repo/semantics/openAccess