Ortiz-Bustos, JosefaCruz, PaulaPérez, YolandaHierro, Isabel del2023-09-212023-09-212022Josefa Ortiz-Bustos, Paula Cruz, Yolanda Pérez, Isabel del Hierro, Prolinate-based heterogeneous catalyst for Knoevenagel condensation reaction: Insights into mechanism reaction using solid-state electrochemical studies, Molecular Catalysis, Volume 524, 2022, 112328, ISSN 2468-8231, https://doi.org/10.1016/j.mcat.2022.1123282468-8231https://hdl.handle.net/10115/24434We gratefully acknowledge financial support from the Ministerio de Ciencia e Innovación, MICINN (project RTI2018-094322-B-I00).The carbon-carbon bond formation is essential to producing relevant organic compounds that exhibit pharmacological and biological properties. In this regard, Knoevenagel and multicondensation reactions have been employed to test the acid-base cooperativity of functionalized mesoporous silica nanoparticles with L-prolinate based groups (Prol-MSN) in comparison with choline hydroxide fragments (Chol-MSN). Thus, Prol-MSN material has shown to be a promising heterogeneous organocatalyst for condensation reactions. The use of electrochemical sensor techniques allowed through cyclic and differential pulse voltammetry studies a better understanding of the catalytic mechanism of Knoevenagel reaction for the Prol-MSN material, including the role of silanol surface groups and protic solvents.engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Basic heterogeneous catalystKnoevenagel reactionElectrochemical techniquesCooperative mechanisminfo:eu-repo/semantics/article10.1016/j.mcat.2022.112328info:eu-repo/semantics/openAccess