Examinando por Autor "Alyne Gourlart Escobar"

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    Aluminum Exposure for 60 days at Human Dietary Levels Impairs Spermatogenesis and Sperm Quality in Rats
    (Elsevier, 2017-10) Caroline Silveira Martinez; Alyne Gourlart Escobar; José Antonio Uranga-Ocio; Franck Maciel Peçanha; Dalton Valentim Vassallo; Christopher Exley; Marta Miguel; Giulia Alessandra Wiggers
    Concerns about environmental aluminum (Al) and reproductive health have been raised. We investigatedthe effects of Al exposure at a human relevant dietary level and a high level exposure to Al. Experiment 1(Lower level) rats were treated orally for 60 days: a) controls – ultrapure water; b) aluminum at 1.5 mg/kgbw/day and c) aluminum at 8.3 mg/kg bw/day. Experiment 2 (High level) rats were treated for 42 days:a) controls – ultrapure water; b) aluminum at 100 mg/kg bw/day. Al decreased sperm count, daily spermproduction, sperm motility, normal morphological sperm, impaired testis histology; increased oxidativestress in reproductive organs and inflammation in testis. Our study shows the specific presence of Alin the germinative cells and, that low concentrations of Al in testes (3.35 _g/g) are sufficient to impairspermatogenesis and sperm quality. Our findings provide a better understanding of the reproductivehealth risk of Al.