Examinando por Autor "Barba, Fructuoso"

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    Ítem
    Microwave-assisted conversion of carbonyl compounds into formylated secondary amines: new contribution to the Leuckart reaction mechanism in N-methylformamide
    (ELSERVIER, 2013-04-03) Barba, Fructuoso; Recio, Javier; Batanero, Belen
    The reductive amination of several carbonyl compounds (Leuckart reaction) has been performed using Nmethylformamide and microwave technology. Under these conditions, a new mechanism is proposed via the initial formation of an imine, followed by reduction to the amine by ‘in situ’ generated formic acid, and further formylation of the amine. Using this methodology, the formyl derivatives of several secondary amines were obtained in good to excellent yields.
  • Miniatura
    Ítem
    One-pot anodic lactonization of Fenchone and Menthone and electrosynthesis of a new magnolione analogue
    (ELSERVIER, 2016-05-25) Batanero, Belen; Recio, Javier; Barba, Fructuoso
    The terpenoid cycloalkanones Fenchone and Menthone have been oxidized at a platinumanode under neutral and alkaline electrolyte conditions. When NaClO4 was used as electrolyte, Fenchone (1a) afforded 1-isopropyl-4- methyl-2-oxa-bicyclo[2.2.1]heptan-3-one, and Menthone (1b) provided the stable lactone 6-isobutyl-4- methyl-tetrahydropyran-2-one, both in good yield.When using Na2CO3 as electrolyte, the oxidation of 1a gave the fragrance-analogue 2,2-dimethyl-3-(2-oxopropyl) cyclopentanone in only one-pot. Mechanism proposals are presented.