Examinando por Autor "Bley, Nadine"

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    UNR/CSDE1 Drives a Post-transcriptional Program to Promote Melanoma Invasion and Metastasis
    (CellPress, 2016-11-14) Wurth, Laurence; Papasaikas, Panagiotis; Olmeda, David; Bley, Nadine; Calvo, Guadalupe T.; Guerrero, Santiago; Cerezo-Wallis, Daniela; Martinez-Useros, Javier; García-Fernández, Maria; Hüttelmaier, Stefan; Soengas, Marisol; Gebauer, Fatima
    RNA binding proteins (RBPs) modulate cancer progression through poorly understood mechanisms. Here we show that the RBP UNR/CSDE1 is overexpressed in melanoma tumors and promotes invasion and metastasis. iCLIP sequencing, RNA sequencing, and ribosome profiling combined with in silico studies unveiled sets of pro-metastatic factors coordinately regulated by UNR as part of RNA regulons. In addition to RNA steady-state levels, UNR was found to control many of its targets at the level of translation elongation/termination. Key pro-oncogenic targets of UNR included VIM and RAC1, as validated by loss- and gain-of-function studies. Our results identify UNR as an oncogenic modulator of melanoma progression, unravel the underlying molecular mechanisms, and identify potential targets for this therapeutically challenging malignancy