Examinando por Autor "Filace, Fabiana"

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    Prodrug Approach: An Overview of Recent Cases
    (ELSEVIER, 2017-02-15) Abet, Valentina; Filace, Fabiana; Javier, Recio; Alvarez-Builla, Julio; Burgos, Carolina
    In this review we highlight the most modern trends in the prodrug strategy. In drug research and development, the prodrug concept has found a number of useful applications. Selected examples of this approach are provided in this paper and they are classified according to the aim of their design.
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    Ítem
    Studies on the preparation of aminobipyridines and bipyridine sultams via an intramolecular free radical pathway
    (ROYAL SOC CHEMISTRY, 2020-03-04) Recio, Javier; Filace, Fabiana; Gala, Elena; Pérez-Redondo, Adrián; Álvarez-Builla, Julio; Burgos, Carolina
    A variety of aminated bipyridines and bipyridine sultams are prepared by intramolecular radical [1,5]-ipso and [1,6]-ortho substitutions, using a sulfonamide as a linker to connect the pyridyl radical to the pyridine under attack. For the cases studied, different regiochemistries are observed depending on the initial position of the sulfonamide linker.