Examinando por Autor "Gil-Crujera, Antonio"

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Apolipoprotein E (ApoE) "4 Genotype (ApoE rs429358—ApoE rs7412 Polymorphisms) Is Not Associated with Long COVID Symptoms in Previously Hospitalized COVID-19 Survivors
(2023-07-10) Fernández-de-las-Peñas, César; Arendt-Nielsen, Lars; Díaz-Gil, Gema; Gómez-Esquer, Francisco; Gil-Crujera, Antonio; Gómez-Sánchez, Stella Maris; Ambite-Quesada, Silvia; Palomar-Gallego, Mª Angustias; Pellicer-Valero, Óscar J; Giordano, Rocco
The role of genetics as a predisposing factor related to an increased risk of developing long COVID symptomatology is under debate. The aim of the current secondary analysis was to identify the association between the Apolipoprotein E (ApoE) gene, a gene affecting cholesterol metabolism and previously associated with a higher risk of SARS-CoV-2 infection and COVID-19 severity, and the development of long COVID in a cohort of individuals who had been hospitalized by SARSCoV-2 infection. Unstimulated whole saliva samples were collected from 287 previously hospitalized COVID-19 survivors. Three genotypes of the ApoE gene (ApoE "2, "3, "4) were obtained based on the combination of ApoE rs429358 and ApoE rs7412 polymorphisms. Participants were asked to self-report the presence of any post-COVID symptom in a face-to-face interview at 17.8 +/- 5.2 months after hospital discharge and medical records were obtained. Each participant reported 3.0 (1.9) post-COVID symptoms. Overall, no significant differences in long COVID symptoms were observed depending on the ApoE genotype (ApoE "2, ApoE "3, ApoE "4). The presence of the ApoE "4 genotype, albeit associated with a higher risk of SARS-CoV-2 infection and COVID-19 severity, did not appear to predispose for the presence of long COVID in our cohort of previously hospitalized COVID-19 survivors.
Are Pain Polymorphisms Associated with the Risk and Phenotype of Post-COVID Pain in Previously Hospitalized COVID-19 Survivors?
(2022-07-26) Fernández-de-las-Peñas, César; Giordano, Rocco; Díaz-Gil, Gema; Gil-Crujera, Antonio; Gómez-Sánchez, Stella Maris; Ambite-Quesada, Silvia; Arendt-Nielsen, Lars
Objective: To investigate the association of different, selected pain polymorphisms with the presence of de novo long-COVID pain symptoms and to analyze the association between these polymorphisms with clinical, sensory-related, cognitive and psychological variables in COVID-19 survivors. Methods: Two hundred and ninety-three (n = 293, 49.5% female, mean age: 55.6 12.9 years) previously hospitalized COVID-19 survivors participated. Three genotypes of the following single nucleotide polymorphisms (SNPs) were obtained from non-stimulated saliva: OPRM1 (rs1799971), COMT (rs4680), BDNF (rs6265), and HTR1B (rs6296) by polymerase chain reactions in all participants. Further, clinical (intensity/duration of pain), sensory-related (sensitization-associated symptoms, neuropathic pain features), psychological (anxiety or depressive levels, sleep quality), and cognitive (catastrophizing, kinesiophobia) variables were collected in those COVID-19 survivors suffering from post-COVID pain. Analyses were carried out to associate clinical features with genotype. Results: Participants were assessed 17.8 +/- 5.2 months after hospitalization. One hundred and seventeen (39.9%) experienced post-COVID pain (particularly of musculoskeletal origin). The distributions of the genotype variants of any SNP were not significantly different between COVID-19 survivors with and without long-term post-COVID pain (all, p > 0.178). No differences in sensitization-associated symptoms, neuropathic pain features, catastrophizing, kinesiophobia levels, anxiety and depressive levels or sleep quality according to the genotype variant in any SNPs were found. No effect of gender was identified. Conclusion: The four SNPs generally associated with pain did not appear to predispose to the development of de novo long-COVID pain symptoms in previously hospitalized COVID-19 survivors. The SNPs were not involved in the phenotypic features of post-COVID pain either.
Carpal tunnel syndrome in the workplace. Triggers, coping strategies, and economic impact: A qualitative study from the perspective of women manual workers
(Elsevier, 2023) Moro-López-Menchero, Paloma; Fernández-de-las-Peñas, César; Güeita-Rodríguez, Javier; Gómez-Sanchez, Stella Maris; Gil-Crujera, Antonio; Palacios-Ceña, Domingo
Background: Carpal tunnel syndrome (CTS) may lead to significant work limitations, especially in female manual workers. There is scarce evidence on the perspective of female manual workers with CTS. Purpose: To explore the perspective of female workers who suffer from CTS regarding triggers, coping strategies, and economic impact. Study design: A qualitative phenomenological study was conducted involving 18 manual workers with CTS diagnosed by the neurology service of a public hospital. Methods: Purposive sampling was applied, and data were collected using in-depth interviews and researchers’ notes. An inductive thematic analysis was applied to identify themes reflecting the participants’ experience. Guba and Lincoln criteria were applied to establish the trustworthiness of the data. Results: The mean age of participants was 40.06 years (SD 9.86). Four themes were identified: (a) coping with work limitations; (b) work activities that aggravate symptoms; (c) relationships at work; and (d) the economic burden of CTS. The effect of work on CTS, daily constraints, work situations that trigger the symptoms, and the strategies used by participants to adapt to their work are described. In addition, they recounted how relationships with managers and coworkers are modified and how CTS affects family finances. Conclusions: The findings describe aggravating factors among working women, coping strategies used, and the social and occupational impact of CTS.
Genetic Association between ACE2 (rs2285666 and rs2074192) and TMPRSS2 (rs12329760 and rs2070788) Polymorphisms with Post-COVID Symptoms in Previously Hospitalized COVID-19 Survivors
(2022-10-24) Fernández-de-las-Peñas, César; Arendt-Nielsen, Lars; Díaz-Gil, Gema; Gómez-Esquer, Francisco; Gil-Crujera, Antonio; Gómez-Sánchez, Stella Maris; Ambite-Quesada, Silvia; Palomar-Gallego, Mª Angustias; Pellicer-Valero, Óscar J; Giordano, Rocco
The aim of the study was to identify the association between four selected COVID-19 polymorphisms of ACE2 and TMPRSS2 receptors genes with the presence of long-COVID symptomatology in COVID-19 survivors. These genes were selected as they associate with the entry of the SARS-CoV-2 virus into the cells, so polymorphisms could be important for the prognoses of long-COVID symptoms. Two hundred and ninety-three (n = 293, 49.5% female, mean age: 55.6 +/- 12.9 years) individuals who had been previously hospitalized due to COVID-19 were included. Three potential genotypes of the following single nucleotide polymorphisms (SNPs) were obtained from non-stimulated saliva samples of participants: ACE2 (rs2285666), ACE2 (rs2074192), TMPRSS2 (rs12329760), TMPRSS2 (rs2070788). Participants were asked to self-report the presence of any post- COVID defined as a symptom that started no later than one month after SARS-CoV-2 acute infection and whether the symptom persisted at the time of the study. At the time of the study (mean: 17.8, SD: 5.2 months after hospital discharge), 87.7% patients reported at least one symptom. Fatigue (62.8%), pain (39.9%) or memory loss (32.1%) were the most prevalent post-COVID symptoms. Overall, no differences in long-COVID symptoms were dependent on ACE2 rs2285666, ACE2 rs2074192, TMPRSS2 rs12329760, or TMPRSS2 rs2070788 genotypes. The four SNPs assessed, albeit previously associated with COVID-19 severity, do not predispose for developing long-COVID symptoms in people who were previously hospitalized due to COVID-19 during the first wave of the pandemic.
Limb Laterality Discrimination, Evoked Sensations and Somatosensory Behavior in Fibromyalgia Syndrome: A Cross-Sectional Study
(MDPI, 2022-07-26) Riquelme-Aguado, Víctor; Gil-Crujera, Antonio; Fernández-Carnero, Josué; Cuenca-Martínez, Ferrán; Gómez-Esquer, Francisco
The main objective of this study was to assess the status of body schema using limb laterality discrimination tasks and pain measurement variables of patients with FMS compared to healthy subjects. The secondary aim was to analyze the relationships between laterality discrimination with respect to somatosensory variables. Thirty female patients with FMS (with a mean age of 52.43 ± 11.82 years) and thirty healthy women (with a mean age of 47.93 ± 5.92 years) were recruited. The main outcome measures were laterality discrimination, referral of evoked sensations, pressure pain threshold and conditioned pain modulation. The main analysis showed that patients with FMS have a longer reaction time for laterality discrimination in hands (hands—20 images, t = 4.044, p < 0.0001, d = 1.04; hands—50 images t = 4.012, p < 0.0001, d = 1.31; feet—20 images t = 2.982, p < 0.01, d = 0.76; feet—50 images, t = 2.159, p < 0.05, d = 0.55). With regard the secondary analysis, patients with FM have higher mechanical hyperalgesia (t = −9.550; p < 0.0001, d = 2.51) and decreased response to conditioned pain modulation compared with healthy subjects (t = 15.519; p < 0.0001, d = 4.17). A positive correlation was found in patients with FMS between greater laterality discrimination ability and better function of conditioned pain modulation (hands r = 0.676, p < 0.0001; feet r = 0.485, p < 0.01). In conclusion, patients with FMS have a longer reaction time and lower accuracy for laterality discrimination, increased mechanical hyperalgesia and decreased conditioned pain modulation compared to healthy subjects. Finally, it seems that there is a positive correlation between greater laterality discrimination ability and better conditioned pain modulation function.