Examinando por Autor "Malvehy, J"

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Dermoscopic Features of Melanocytic Nevi in Seven Different Anatomical Locations in Patients With Atypical Nevi Syndrome
(LIPPINCOTT WILLIAMS & WILKINS, 2013) Gamo, Reyes; Malvehy, J; Puig, Susana; Fuentes, Manuel Enrique; Naz, Elena; Gómez de la Fuente, Enrique; Calzado, Leticia; Sánchez Gilo, Araceli; Vicente, Javier Vicente; López Estebaranz, Jose Luis
BACKGROUND Dermoscopic screening facilitates early detection of melanoma and is recommended in patients with multiple or atypical nevi. OBJECTIVES To investigate whether dermoscopic features of acquired melanocytic nevi differ between six body sites (neck, axilla, pectoral area, shoulders, buttocks, legs) and the trunk. METHODS AND MATERIALS One hundred six patients with atypical nevi syndrome from a Digital Dermoscopy Unit were evaluated for the presence of nevi in each of seven body sites, and nevi representative of each region were selected as the predominant nevi. Dermoscopic features of 684 melanocytic nevi located in seven different body sites were analyzed. RESULTS Globular and globular-homogeneous pattern nevi showed a cephalad distribution. Nevi at the neck, axilla, shoulders, and pectoral area showed a higher proportion of globular and globular-homogeneous patterns than other locations (p < .001). Comma vessels were also more frequent on the neck, axillary area, and shoulders (p < .001). A reticular pattern was more frequent on caudal areas (legs, buttocks and lower back, and abdomen; p < .001). CONCLUSIONS Dermoscopic differences were found in different body areas. This information should be considered in the evaluation of lesions in patients with atypical nevus syndrome. The authors have indicated no significant interest with commercial supporters
Early outcome of a 31-gene expression profile test in 86 AJCC stage IB-II melanoma patients. A prospective multicentre cohort study
(Wiley, 2019) Podlipnik, S; Carrera, C; Boada, A; Richarz, N; Lopez Estebaranz, JL; Pinedo Moraleda, F; Elosua Gonzalez, M; Martin Gonzalez, MM; Carrillo Gijon, R; Redondo, P; Moreno, E; Malvehy, J; Puig, S
Background The clinical and pathological features of primary melanoma are not sufficiently sensitive to accurately pre dict which patients are at a greater risk of relapse. Recently, a 31-gene expression profile (DecisionDx-Melanoma) test has shown promising results. Objectives To evaluate the early prognostic performance of a genetic signature in a multicentre prospectively evalu ated cohort. Methods Inclusion of patients with AJCC stages IB and II conducted between April 2015 and December 2016. All patients were followed up prospectively to assess their risk of relapse. Prognostic performance of this test was evaluated individually and later combined with the AJCC staging system. Prognostic accuracy of disease-free survival was deter mined using Kaplan–Meier curves and Cox regression analysis. Results of the gene expression profile test were desig nated as Class 1 (low risk) and Class 2 (high risk). Results Median follow-up time was 26 months (IQR 22–30). The gene expression profile test was performed with 86 patients; seven had developed metastasis (8.1%) and all of them were in the Class 2 group, representing 21.2% of this group. Gene expression profile was an independent prognostic factor for relapse as indicated by multivariate Cox regression analysis, adjusted for AJCC stages and age. Conclusions This prospective multicentre cohort study, performed in a Spanish Caucasian cohort, shows that this 31- gene expression profile test could correctly identify patients at early AJCC stages who are at greater risk of relapse. We believe that gene expression profile in combination with the AJCC staging system could well improve the detection of patients who need intensive surveillance and optimize follow-up strategies