Examinando por Autor "Mendez-Arriaga, Jose Manuel"

Mostrando 1 - 3 de 3

Antiparasitic activity against trypanosomatid diseases and novel metal complexes derived from the first time characterized 5-phenyl-1, 2, 4-triazolo [1, 5-a] pyrimidi-7 (4H)-one
(Elsevier, 2017-10-01) Mendez-Arriaga, Jose Manuel; Esteban-Parra, Gines Miguel; Juarez, Maria Jose; Rodríguez-Diéguez, Antonio; Sanchez-Moreno, Manuel; Isac-García, Joaquin; Salas, Juan Manuel
A serie of isostructural complexes with general formula [M(ftpO)2(H2O)4] have been obtained from reaction between the first time characterized triazolopyrimidine derivative 5-phenyl-1,2,4-triazolo[1,5-a]pyrimidi-7(4H)-one (HftpO) (1) and first row transition nitrates (M = Cu (2), Co (3), Ni (4) and Zn (5)). A copper complex with formula [Cu(HftpO)2(NO3)2(H2O)2]· H2O (6) was also isolated. HftpO and their metal complexes have been characterized by spectroscopic and thermal analysis and their crystal structures have been solved by X-ray diffraction methods. The isostructural compounds are mononuclear complexes where the triazolopyrimidine ligand acts as monodentate ligand through N3 nitrogen position. The crystal structure of these novel bis-5-phenyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one-tetraaquo metal complexes offers an excellent opportunity at these complexes to acts as potential building blocks. Also, the antiparasitic activity of HftpO ligand against different leishmania and trypanosome strains has been studied.
First-Row Transition 7-Oxo-5-phenyl-1,2,4-triazolo[1,5-a]pyrimidine Metal Complexes: Antiparasitic Activity and Release Studies
(MDPI, 2023-09-28) Martin-Montes, Alvaro; Jimenez-Falcao, Sandra; Gomez-Ruiz, Santiago; Marin, Clotilde; Mendez-Arriaga, Jose Manuel
Leishmaniasis and Chagas disease are still considered neglected illnesses due to the lack of investment in research, despite the fact that almost one million new cases are reported every year. Four 7-oxo-5-phenyl-1,2,4-triazolo[1,5-a]pyrimidine (HftpO) first-row transition complexes (Cu, Co, Ni, Zn) have been studied for the first time in vitro against five different species of Leishmania spp. (L. infantum, L. braziliensis, L. donovani, L. peruviana and L. mexicana) as well as Trypanosoma cruzi, showing higher efficacy than the reference commercial drugs. UV and luminescence properties were also evaluated. As a proof of concept, anchoring of a model high-effective-metal complex as an antiparasitic agent on silica nanoparticles was carried out for the first time, and drug-release behaviour was evaluated, assessing this new approach for drug vehiculation.
In vitro leishmanicidal activity of copper (II) 5, 7-dimethyl-1, 2, 4-triazolo [1, 5-a] pyrimidine complex and analogous transition metal series
(Elsevier, 2020-01-15) Mendez-Arriaga, Jose Manuel; Rodríguez-Diéguez, Antonio; Sanchez-Moreno, Manuel
A series of triazolopyrimidine transition metals complexes have been synthesized by the reaction between the derivative 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine (dmtp) with M(NO3)2·XH2O (M = Cu(II), Co(II), Ni(II) and Zn(II)). These four compounds have been characterized by spectroscopic and thermal analysis and the crystal structure of the Cu(II) one has been solved by X-ray diffraction methods. The in vitro antiparasitic activity of these complexes against four leishmania spp. strands and their toxicity against macrophage host cells have also been studied, in order to elucidate the influence of different metal centres in the leishmanicidal effect to fight neglected tropical diseases.