Examinando por Autor "Novakova, Olga"

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    Increasing DNA reactivity and in vitro antitumor activity of trans diiodido Pt(II) complexes with UVA light
    (Elsevier Sciencie Inc., 2015-07-21) Navas, Francisco; Perfhal, Stefanie; Garino, Claudio; Salassa, Luca; Novakova, Olga; Navarro-Ranninger, Carmen; Bednarski, Patrick J.; Malina, Jaroslav; Gómez Quiroga, Adoración
    Trans diiodido platinum(II) complexes bearing the same as well as different aliphatic amines (mixed-amines) have interesting biological activity; cytotoxicity and interactions with some important biological models have already been demonstrated. Herein we described the interaction of such compounds with ct-DNA, supercoiled and linearized plasmid DNA and 5-GMP. Interestingly, UV irradiation of these compounds results in an increase in reactivity towards DNA and 5-GMP in such model systems. Additionally, the cytotoxicity of the trans-Pt(II) complexes towards human cancer cells is noticeably increased when treatment is combined for 90 min with UVA-irradiation. With this work we provide evidence that trans diiodido compounds can be activated by UVlight over relatively short treatment times.