Examinando por Autor "Patel, Sarju"

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    Bacterial Cu(+)-ATPases: models for molecular structure-function studies.
    (Oxford University Press, 2016-07-22) Argüello, José; Patel, Sarju; Quintana, Julia
    The early discovery of the human Cu(+)-ATPases and their link to Menkes and Wilson's diseases brought attention to the unique role of these transporters in copper homeostasis. The characterization of bacterial Cu(+)-ATPases has significantly furthered our understanding of the structure, selectivity and transport mechanism of these enzymes, as well as their interplay with other elements of Cu(+) distribution networks. This review focuses on the structural-functional insights that have emerged from studies of bacterial Cu(+)-ATPases at the molecular level and how these observations have contributed to drawing up a comprehensive picture of cellular copper homeostasis.