Examinando por Autor "Pinedo, Fernando"

Mostrando 1 - 2 de 2

Focal recurrent episodic hyperhidrosis on the forearm
(SPRINGER, 2001) Borrego, Leopoldo; López Estebaranz, Jose Luis; Vicente, Javier; Sols, Miriam; Pinedo, Fernando
El estudio presenta el caso de un paciente con hiperhidrosis focal recurrente episódica, una condición caracterizada por episodios recurrentes de sudoración excesiva en áreas localizadas del cuerpo, en este caso, en el antebrazo. Se describe la presentación clínica, los factores desencadenantes y la evolución de la hiperhidrosis en el paciente, así como los métodos de diagnóstico utilizados para confirmar la condición. Se discuten las opciones de tratamiento disponibles para la hiperhidrosis focal recurrente episódica y se describe el enfoque terapéutico utilizado en este caso particular.
The overlap with metabolic dysfunction-associated steatotic liver disease negatively affects outcomes of primary biliary cholangitis
(Wiley, 2024-06-25) Hernández-Pérez, María; Riado, Daniel; Pena, Eva; Méndez, Carmen; Pinedo, Fernando; Ramos, Paloma; Castillo, Pilar; Romero, Miriam; Fernández-Rodríguez, Conrado; Olveira, Antonio
Background and Aims: The relationship between primary biliary cholangitis (PBC)and metabolic dysfunction-associated steatotic liver disease, and its impact on treat-ment response and prognosis, remains underexplored.Methods: Patient cohort from two centres comprising long-term follow-up data.All patients had histologically confirmed PBC. Biopsies were classified according toNon-Alcoholic Steatohepatitis Clinical Research Network. Diagnosis of metabolicdysfunction-associated steatotic liver disease was established when steatosis ex-ceeded 5%, along with at least one metabolic risk factor. Patients with specific aetiol-ogies of steatosis, other liver diseases, incomplete results and inadequate treatmentwith ursodeoxycholic acid were excluded. Data from patients initiating second-linetreatment were censored. Treatment response was assessed using the Toronto, ParisII and AST-to-platelet at 12-month criteria. The UK PBC and Globe scores, and liverevents were utilized as outcome measures.Results: The study included 129 patients, 36 showing histologically confirmed over-lap between PBC and steatosis. Patients with overlap showed worse prognosis ac-cording to Paris II (61.1% vs. 33.3%, p = 0.004), Toronto (52.5% vs. 24.7%, p = 0.002),AST-to-platelet 12-month >0.54 (36.1% vs. 17.2%, p = 0.021), Globe >0.30 (49.2% vs.29.2%, p = 0.033) and UK PBC at 5, 10 and 15 years (p ≤ 0.001). Liver-related mortalityand liver transplant were more prevalent in the overlap group (p = 0.001). In the mul-tivariate analysis, steatosis, dyslipidaemia and advanced fibrosis were independentlyassociated to worse outcomes.Conclusions: Our findings suggest that metabolic dysfunction-associated steatoticliver disease worsens the prognosis of PBC