Examinando por Autor "Pinedo Moraleda, F"

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Early outcome of a 31-gene expression profile test in 86 AJCC stage IB-II melanoma patients. A prospective multicentre cohort study
(Wiley, 2019) Podlipnik, S; Carrera, C; Boada, A; Richarz, N; Lopez Estebaranz, JL; Pinedo Moraleda, F; Elosua Gonzalez, M; Martin Gonzalez, MM; Carrillo Gijon, R; Redondo, P; Moreno, E; Malvehy, J; Puig, S
Background The clinical and pathological features of primary melanoma are not sufficiently sensitive to accurately pre dict which patients are at a greater risk of relapse. Recently, a 31-gene expression profile (DecisionDx-Melanoma) test has shown promising results. Objectives To evaluate the early prognostic performance of a genetic signature in a multicentre prospectively evalu ated cohort. Methods Inclusion of patients with AJCC stages IB and II conducted between April 2015 and December 2016. All patients were followed up prospectively to assess their risk of relapse. Prognostic performance of this test was evaluated individually and later combined with the AJCC staging system. Prognostic accuracy of disease-free survival was deter mined using Kaplan–Meier curves and Cox regression analysis. Results of the gene expression profile test were desig nated as Class 1 (low risk) and Class 2 (high risk). Results Median follow-up time was 26 months (IQR 22–30). The gene expression profile test was performed with 86 patients; seven had developed metastasis (8.1%) and all of them were in the Class 2 group, representing 21.2% of this group. Gene expression profile was an independent prognostic factor for relapse as indicated by multivariate Cox regression analysis, adjusted for AJCC stages and age. Conclusions This prospective multicentre cohort study, performed in a Spanish Caucasian cohort, shows that this 31- gene expression profile test could correctly identify patients at early AJCC stages who are at greater risk of relapse. We believe that gene expression profile in combination with the AJCC staging system could well improve the detection of patients who need intensive surveillance and optimize follow-up strategies
Squamous cell carcinoma of the lip. A retrospective study of 146 patients
(Wiley, 2012) Gutierrez Pacual, M; Vicente Martín, FJ; Fernández Alvarez, JG; Martín López, R; Pinedo Moraleda, F; Lopez Estebaranz, JL
Background Squamous cell carcinoma of the lip (SCCL) accounts for 90% of all tumours of the oral cavity. We present a series of 146 patients with SCCL studied in our hospital. Objective To evaluate and identify the primary tumour parameters related to local and lymph node recurrence. Methods We retrospectively analysed the clinical characteristics, surgical procedures and tumour recurrences of the 146 patients diagnosed with SCCL in Hospital Universitario Fundacio´ n Alcorco´ n (Spain). Results A total of 122 of the 146 patients (91.7%) showed tumour stage £T1N0M0 at diagnosis, and 11 (8.3%) showed stage >T1N0M0. Local recurrences were observed in 11 of the 146 patients (7.5%), and five patients (3.4%) developed lymph node metastases during follow-up. Kaplan–Meier survival analysis showed an increased tumour size to imply a greater risk of local recurrence (P = 0.025). The probability of local recurrence over the 24 months of follow-up was 1% for tumour stages £T1N0M0 and 20% for stages ‡T1N0M0. There appears to be a greater tendency towards local relapse in male patients, in smokers, patients living in rural areas, in lower lip tumours and in those patients showing infiltration at physical exploration. Eleven patients (8%) died during follow-up, although in only two of them (18%), SCCL was the cause of death. Conclusion The low tumour stage of our patients may explain the few local and lymph node disease recurrences seen in our study. We have shown tumour size to be directly related to the probability of local recurrence