Examinando por Autor "Salas, Juan Manuel"

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Antiparasitic activity against trypanosomatid diseases and novel metal complexes derived from the first time characterized 5-phenyl-1, 2, 4-triazolo [1, 5-a] pyrimidi-7 (4H)-one
(Elsevier, 2017-10-01) Mendez-Arriaga, Jose Manuel; Esteban-Parra, Gines Miguel; Juarez, Maria Jose; Rodríguez-Diéguez, Antonio; Sanchez-Moreno, Manuel; Isac-García, Joaquin; Salas, Juan Manuel
A serie of isostructural complexes with general formula [M(ftpO)2(H2O)4] have been obtained from reaction between the first time characterized triazolopyrimidine derivative 5-phenyl-1,2,4-triazolo[1,5-a]pyrimidi-7(4H)-one (HftpO) (1) and first row transition nitrates (M = Cu (2), Co (3), Ni (4) and Zn (5)). A copper complex with formula [Cu(HftpO)2(NO3)2(H2O)2]· H2O (6) was also isolated. HftpO and their metal complexes have been characterized by spectroscopic and thermal analysis and their crystal structures have been solved by X-ray diffraction methods. The isostructural compounds are mononuclear complexes where the triazolopyrimidine ligand acts as monodentate ligand through N3 nitrogen position. The crystal structure of these novel bis-5-phenyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one-tetraaquo metal complexes offers an excellent opportunity at these complexes to acts as potential building blocks. Also, the antiparasitic activity of HftpO ligand against different leishmania and trypanosome strains has been studied.
Highly Stable Double‐Stranded DNA Containing Sequential Silver (I)‐Mediated 7‐Deazaadenine/Thymine Watson–Crick Base Pairs
(Wiley, 2016-05-17) Santamaría‐Díaz, Noelia; Mendez‐Arriaga, Jose Manuel; Salas, Juan Manuel; Galindo, Miguel A
The oligonucleotide d(TX)9, which consists of an octadecamer sequence with alternating non-canonical 7-deazaadenine (X) and canonical thymine (T) as the nucleobases, was synthesized and shown to hybridize into double-stranded DNA through the formation of hydrogen-bonded Watson–Crick base pairs. dsDNA with metal-mediated base pairs was then obtained by selectively replacing W-C hydrogen bonds by coordination bonds to central silver(I) ions. The oligonucleotide I adopts a duplex structure in the absence of Ag+ ions, and its stability is significantly enhanced in the presence of Ag+ ions while its double-helix structure is retained. Temperature-dependent UV spectroscopy, circular dichroism spectroscopy, and ESI mass spectrometry were used to confirm the selective formation of the silver(I)-mediated base pairs. This strategy could become useful for preparing stable metallo-DNA-based nanostructures.