Examinando por Autor "Arendt Nielsen, Lars"

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    Association of OPRM1 rs1799971, HTR1B rs6296 and COMT rs4680 polymorphisms with clinical phenotype among women with fibromyalgia
    (Nature, 2024-05-17) Fernández de Las Peñas, César; Ambite Quesada , Silvia; Fernández Méndez, Luis M; Jiménez Antona, Carmen; Gómez Calero, Cristina; Pocinho, Ricardo; Valera Calero, Juan Antonio; Cigarán Méndez, Margarita; Arendt Nielsen, Lars
    El objetivo fue investigar la asociación entre tres polimorfismos del dolor seleccionados y variables clínicas, funcionales, sensoriales, psicofísicas, psicológicas o cognitivas en una muestra de mujeres con fibromialgia (FMS). Ciento veintitrés (n = 123) mujeres con FMS completaron variables demográficas (edad, altura, peso), clínicas (años con dolor, intensidad del dolor en reposo y durante las actividades de la vida diaria), funcionales (calidad de vida, función física), sensoriales (síntomas asociados a la sensibilización y síntomas asociados a la neuropatía), psicofísicas (umbrales de dolor a la presión), psicológicas (calidad del sueño, nivel depresivo y de ansiedad) y cognitivas (catastrofización del dolor, kinesiofobia). Estos tres genotipos de los polimorfismos de nucleótido único OPRM1 rs1799971, HTR1B rs6296 y COMT rs4680 se obtuvieron mediante reacciones en cadena de la polimerasa a partir de una colección de saliva entera no estimulada. No se identificaron diferencias significativas en las variables demográficas, clínicas, funcionales, sensoriales, psicofísicas, psicológicas y cognitivas en función del genotipo OPRM1 rs1799971, HTR1B rs6296 o COMT rs4680 en nuestra muestra de mujeres con FMS. Un análisis multinivel tampoco reveló ninguna interacción significativa gen-gen entre OPRM1 rs1799971 x HTR1B rs6296, OPRM1 rs1799971 x COMT rs4680 y HTR1B rs6296 x COMT rs4680 para ninguno de los resultados investigados. Este estudio reveló que tres polimorfismos de un solo nucleótido, OPRM1 rs1799971, HTR1B rs6296 o COMT rs4680, mayoritariamente asociados con el dolor crónico, no estaban implicados en las características fenotípicas del FMS. La posible interacción gen-gen y su asociación con el fenotipo clínico en mujeres con FMS debería investigarse más a fondo en futuros estudios que incluyan muestras de gran tamaño
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    Exploring the trajectory curve of long-term musculoskeletal post-COVID pain symptoms in hospitalized COVID-19 survivors: a multicenter study
    (Lippincott, Williams & Wilkins, 2023-02-01) Fernández de las Peñas , César; Cancela Cilleruelo, Ignacio; Moro López-Menchero, Paloma; Rogríguez Jiménez, Jorge; Pellicer Valero, Oscar J; Martín Guerrero, Jose D; Arendt Nielsen, Lars
    This multicenter cohort study investigated the prevalence of musculoskeletal post-COVID pain during the first year after the infection with mosaic plots and an exponential bar plot model and its associated risk factors. Patients hospitalized because of COVID-19 in 5 hospitals of Madrid (Spain) were scheduled for a telephone interview at 2 follow-up periods after hospitalization for collecting data about musculoskeletal post-COVID pain. Hospitalization and clinical data were collected from hospital medical records. From 2000 patients initially recruited, 1593 (44.6% women, age: 61 ± 15 years) were assessed at T0 (hospital admission), T1 (mean: 8.0 ± 1.5 months after discharge), and T2 (mean: 13.2 ± 1.5 months after discharge). The prevalence of musculoskeletal pain (myalgia) was 30.3% (n = 483) at T0, increased to 43.4% (n = 692) at T1, and decreased to 37.8% (n = 603) at T2. The trajectory curve revealed a decreasing prevalence trend of musculoskeletal post-COVID pain the following years after hospitalization. According to the presence of pre-existing pain symptoms, the prevalence of new-onset post-COVID pain was 75.9%. Female sex (odds ratio [OR] 1.593, 95% confidence interval [CI] 1.148-2.211), history of musculoskeletal pain (OR 1.591, 95% CI 1.211-2.07), the presence of myalgia (OR 1.371, 95% CI 1.032-1.821) or headache (OR 2.278, 95% CI 1.622-3.199) at hospitalization, the days of hospitalization (OR 1.013, 95% CI 1.000-1.025), and the presence of post-COVID pain at T1 (OR 11.02, 95% CI 8.493-14.305) were factors associated with musculoskeletal post-COVID pain 1 year after hospitalization. In conclusion, musculoskeletal post-COVID pain remains highly prevalent 1 year after hospitalization. Female sex, previous history of pain symptoms, pain symptoms at onset, and days at hospit
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    Myalgia as a symptom at hospital admission by severe acute respiratory syndrome coronavirus 2 infection is associated with persistent musculoskeletal pain as long-term post-COVID sequelae: a case-control study
    (Lippincott, Williams & Wilkins, 2021-12) Fernández de las Peñas, César; Rodríguez Jiménez, Jorge; Fuensalida Novo, Stella; Palacios Ceña, María; Gómez Mayordomo, Víctor; Florencio, Lidiane L.; Hernández Barrera, Valentín; Arendt Nielsen, Lars
    This study investigated the association between COVID-related myalgia experienced by patients at hospital admission and the presence of post-COVID symptoms. A case-control study including patients hospitalised due to COVID-19 between February 20 and May 31, 2020, was conducted. Patients reporting myalgia and patients without myalgia at hospital admission were scheduled for a telephone interview 7 months after hospital discharge. Hospitalisation and clinical data were collected from medical records. A list of post-COVID symptoms with attention to musculoskeletal pain was evaluated. Anxiety and depressive symptoms, and sleep quality were likewise assessed. From a total of 1200 hospitalised patients with COVID-19, 369 with and 369 without myalgia at hospital admission were assessed 7.2 months (SD 0.6) after hospital discharge. A greater proportion (P = 0.03) of patients with myalgia at hospital admission (20%) showed ≥3 post-COVID symptoms when compared with individuals without myalgia (13%). A higher proportion of patients presenting myalgia (odds Rratio 1.41, 95% confidence interval 1.04-1.90) exhibited musculoskeletal post-COVID pain when compared to those without myalgia. The prevalence of musculoskeletal post-COVID pain in the total sample was 38%. Fifty percent of individuals with preexisting musculoskeletal pain experienced a worsening of their symptoms after COVID-19. No differences in fatigue, dyspnoea, anxiety/depressive levels, or sleep quality were observed between myalgia and nonmyalgia groups. The presence of myalgia at hospital admission was associated with preexisting history of musculoskeletal pain (OR 1.62, 95% confidence interval 1.10-2.40). In conclusion, myalgia at the acute phase was associated with musculoskeletal pain as long-term post-COVID sequelae. In addition, half of the patients with preexisting pain conditions experienced a persistent exacerbation of their previous syndromes.
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    Prevalence of Musculoskeletal Post-COVID Pain in Hospitalized COVID-19 Survivors Depending on Infection with the Historical, Alpha or Delta SARS-CoV-2 Variant
    (MDPI, 2022-08-11) Fernández de las Peñas, César; Cancela Cilleruelo, Ignacio; Moro López-Menchero, Paloma; Rodríguez Jiménez, Jorge; Gómez Mayordomo, Víctor; Torres Macho, Juan; Pellicer Valero, Oscar J; Martín Guerrero , José D; Hernández Barrera, Valentín; Arendt Nielsen, Lars
    We compared the prevalence of musculoskeletal post-COVID pain between previously hospitalized COVID-19 survivors infected with the historical, Alpha or Delta SARS-CoV-2 variant. Data about musculoskeletal post-COVID pain were systematically collected through a telephone interview involving 201 patients who had survived the historical variant, 211 who had survived the Alpha variant and 202 who had survived the Delta variant six months after hospital discharge. Participants were recruited from non-vaccinated individuals hospitalized due to SARS-CoV-2 infection in one hospital of Madrid (Spain) during three different waves of the pandemic (historical, Alpha or Delta variant). Hospitalization and clinical data were collected from hospital medical records. In addition, anxiety/depressive levels and sleep quality were also assessed. The prevalence of musculoskeletal post-COVID pain was higher (p = 0.003) in patients infected with the historical variant (47.7%) than in those infected with the Alpha (38.3%) or Delta (41%) variants. A significantly (p = 0.002) higher proportion of individuals infected with the historical variant reported generalized pain (20.5%) when compared with those infected with the other variants. The prevalence of new-onset post-COVID musculoskeletal pain reached 80.1%, 75.2% and 79.5% of patients infected with the historical, Alpha or Delta variants, respectively. No specific risk factors for developing post-COVID pain were identified depending on the SARS-CoV-2 variant. In conclusion, this study found that musculoskeletal post-COVID pain is highly prevalent in COVID-19 survivors six months after hospital discharge, with the highest prevalence and most generalized pain symptoms in individuals infected with the historical variant. Approximately 50% developed "de novo" post-COVID musculoskeletal pain symptoms.
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    Widespread Pressure Pain Sensitivity over Nerve Trunk Areas in Women with Frequent Episodic Tension-Type Headache as a Sign of Central Sensitization
    (Malden, MA : Blackwell Science, Inc., c2000, 2020) Caamaño Barrios, Leandro Hernán; Galán del Río, Fernando; Fernández de las Peñas, César; Plaza Manzano, Gustavo; Arendt Nielsen, Lars; Ortega Santiago, Ricardo
    En estudios previos se observó que la presencia de sensibilidad al dolor por presión generalizada en pacientes con cefalea de tipo tensional. Sin embargo, la mayoría de los estudios evaluaron la sensibilidad al dolor por presión en el tejido muscular. Nuestro objetivo era investigar la diferencia en la sensibilidad al dolor por presión sobre las zonas musculoesqueléticas y nerviosas sintomáticas y distantes entre las mujeres con cefalea tensional episódica frecuente (FETTH) y los sujetos sanos. Participaron 32 mujeres con FETTH y 32 mujeres sanas emparejadas. Se evaluó bilateralmente el umbral de dolor a la presión (PPT) en varios troncos nerviosos (occipital mayor, mediano, radial, cubital, peroneo común, tibial posterior) y estructuras musculoesqueléticas (músculo temporal, articulación C5/C6, tibial anterior) por un evaluador cegado a la condición del sujeto. Se utilizó un diario de cefaleas de cuatro semanas para recoger la intensidad, frecuencia y duración de la cefalea. Se utilizó la Escala Hospitalaria de Ansiedad y Depresión para determinar los niveles de ansiedad y depresión. El análisis de covarianza halló PPT generalizados y bilaterales más bajos en todos los troncos nerviosos y estructuras musculoesqueléticas en las mujeres con dolor FETTH (P < 0,001). No se halló ningún efecto significativo de los niveles de ansiedad y depresión sobre las PPT (todas las p > 0,222). La PPT sobre el músculo temporal se correlacionó negativamente de forma significativa con la intensidad del dolor de cabeza. Este estudio encontró hipersensibilidad generalizada al dolor por presión tanto sobre troncos nerviosos como sobre estructuras musculoesqueléticas en mujeres con FETTH, lo que sugiere que la presencia de un procesamiento nociceptivo central alterado no se restringe únicamente a áreas musculoesqueléticas, por ejemplo, músculos, sino también al dolor evocado a partir de la provocación directa de los troncos nerviosos por presión. También es posible que el tratamiento del tejido nervioso provoque una disminución de las características de sensibilización central y cefalea Este estudio formó parte de un proyecto de tesis doctoral del Dr. Leandro Herman Caamaño en el que participé como co-director junto al Dr. Ricardo Ortega Santiago, miembro del equipo de investigación del Prof. César Fernández de las Peñas constituyendo ambos una referencia internacional en el campo de la valoración y tratamiento del dolor músculo-esquelético, en particular en el ámbito de la cefalea tensional