Examinando por Autor "Wilkman-Jorgensen, Phillip"

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Imported cysticercosis in Spain: A retrospective case series from the +REDIVI Collaborative Network
(Elsevier, 2020-04-23) Herrador, Zaida; Pérez-Molina, José A.; Henriquez-Camacho, César; Rodriguez-Guardado, Azucena; Bosch-Nicolau, Pau; Calabuig, Eva; Dominguez-Castellano, Angel; Pérez-Jacoiste, Maria Asunción; Ladrón de Guevara, Maria Concepción; Mena, Ana; Ruiz-Giardin, José Manuel; Torrús, Diego; Wilkman-Jorgensen, Phillip; Benito, Agustín; López-Vélez, Rogelio
Abstract Background Neurocysticercosis (NCC) is the most common parasitic neurological disease worldwide and a major cause of epilepsy. Spain is the country reporting the highest number of NCC imported cases in Europe. Methodology Retrospective case series of NCC patients registered in the +REDIVI Network from October 1, 2009 to July 2018. A specific questionnaire, including clinical and diagnostic characteristics, was created and sent to the collaborator centers. Results 46 cases were included in the analysis. 55% were male, mean age of 40 years. 95.6% were migrants. The median duration since migration from an endemic area was 10 years. Predominant nationalities were Ecuadorians (50%) and Bolivians (30.4%). Frequent locations were parenchymal (87%), subarachnoid (26.1%) and intraventricular cysts (10.9%). Serological analysis was performed in 91.3%, being 54.8% positive. Most prevalent clinical manifestations were persistent headache (60.9%), epilepsy (43.5%) and visual changes (13%). Patients were mainly treated with albendazole (76.1%), corticosteroids (67.4%), and anticonvulsionants (52.2%). 82.5% had a favorable clinical outcome. Conclusions Most NCC cases were long-standing migrants. Few clinical differences were observed depending on the cysticerci location. The treatment was often not according to current recommendations, and no uniform criteria were followed when it came to the therapeutic regimen. NCC case management in Spain (including clinician awareness and laboratory capacity improvements) needs to be strengthened.
Latent and active tuberculosis infections in migrants and travellers: A retrospective analysis from the Spanish +REDIVI collaborative network
(ELSEVIER, 2019-07-29) Wilkman-Jorgensen, Phillip; López-Vélez, Rogelio; Llenas-García, Jara; Treviño, Begoña; Pascual, Reyes; Molina, Israel; Dominguez, Angel; Torrús, Diego; Ruiz Giardín, José Manuel; Monge-Maillo, Begoña; Norman, Francesca; Romero, Monica; Pérez-Molina, José A.
Background: Tuberculosis (TB) is the leading cause of infectious disease mortality worldwide. We analysed active and latent TB infections (LTBI) from the Spanish Network for the Study of Imported Infectious Diseases by Travellers and Immigrants (+REDIVI). Methods: Observational, retrospective, multicentre study of TB and LTBI registered in the +REDIVI network from October 2009 to December 2016. Results: Of 1008 cases of LTBI, 884 (87.7%) were immigrants; 93 (4.5%), immigrants visiting friends and relatives (VFR); 2 (0.9%), VFR-travellers; and 29 (1.1%), travellers. Absolute (N=157 vs. N=75) and relative (12.5% vs. 5.9%) frequency decreased over the study period (p=0.003). Median time to diagnosis was 24.6 months (females 50.3 vs males 11.9; p<0.001). Of 448 TB cases, 405 (90.4%) were in immigrants; 30 (6.7%), VFR-immigrants; 6 (1.3%), VFR-travellers; and 7 (1.6%), travellers. Median time to diagnosis was 62.5 months (females 86.6 vs males 70.1; p=0.0075). There were 8 multidrug resistant TB cases and 1 extensively drug resistant case of TB, all in immigrants. Conclusion: TB was frequently diagnosed more than 5 years after arrival in Spain. Screening programmes for TB and LTBI in immigrants should be considered beyond this time point. Women showed a higher diagnostic delay for both latent and active TB.