dc.contributor.author | Medina-Gómez, Gema | |
dc.date.accessioned | 2014-05-28T13:55:00Z | |
dc.date.available | 2014-05-28T13:55:00Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Mitochondria and endocrine function of adipose tissue
Medina-Gomez G.
(2012) Best Practice and Research: Clinical Endocrinology and Metabolism, 26 (6) , pp. 791-804. | |
dc.identifier.issn | 1521-690X | |
dc.identifier.uri | http://hdl.handle.net/10115/12381 | |
dc.description.abstract | Excess of adipose tissue is accompanied by an increase in the risk of developing
insulin resistance, type 2 diabetes (T2D) and other complications. Nevertheless, total or
partial absence of fat or its accumulation in other tissues (lipotoxicity) is also associated to
these complications. White adipose tissue (WAT) was traditionally considered a
metabolically active storage tissue for lipids while brown adipose tissue (BAT) was
considered as a thermogenic adipose tissue with higher oxidative capacity. Nowadays,
WAT is also considered an endocrine organ that contributes to energy homeostasis.
Experimental evidence tends to link the malfunction of adipose mitochondria with the
development of obesity and T2D. This review discusses the importance of mitochondrial
function in adipocyte biology and the increased evidences of mitochondria dysfunction in
these epidemics. New strategies targeting adipocyte mitochondria from WAT and BAT are
also discussed as therapies against obesity and its complications in next future. | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation | S2010/BMD-2423 | |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 España | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | |
dc.subject | Bioquímica | es |
dc.subject | mitochondria | es |
dc.subject | white adipose tissue | es |
dc.subject | brown adipose tissue | es |
dc.subject | obesity | es |
dc.subject | type 2 diabetes | es |
dc.subject | lipotoxicity | es |
dc.subject | reactive oxygen species | es |
dc.subject | beta-oxidation | es |
dc.title | Mitochondria and endocrine function of adipose tissue | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | 10.1016/j.beem.2012.06.002 | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | |
dc.subject.unesco | 3205.02 Endocrinología | es |
dc.description.departamento | Bioquímica, Fisiología y Genética Molecular | |