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Mitochondria and endocrine function of adipose tissue

dc.contributor.authorMedina-Gómez, Gema
dc.date.accessioned2014-05-28T13:55:00Z
dc.date.available2014-05-28T13:55:00Z
dc.date.issued2012
dc.identifier.citationMitochondria and endocrine function of adipose tissue Medina-Gomez G. (2012) Best Practice and Research: Clinical Endocrinology and Metabolism, 26 (6) , pp. 791-804.
dc.identifier.issn1521-690X
dc.identifier.urihttp://hdl.handle.net/10115/12381
dc.description.abstractExcess of adipose tissue is accompanied by an increase in the risk of developing insulin resistance, type 2 diabetes (T2D) and other complications. Nevertheless, total or partial absence of fat or its accumulation in other tissues (lipotoxicity) is also associated to these complications. White adipose tissue (WAT) was traditionally considered a metabolically active storage tissue for lipids while brown adipose tissue (BAT) was considered as a thermogenic adipose tissue with higher oxidative capacity. Nowadays, WAT is also considered an endocrine organ that contributes to energy homeostasis. Experimental evidence tends to link the malfunction of adipose mitochondria with the development of obesity and T2D. This review discusses the importance of mitochondrial function in adipocyte biology and the increased evidences of mitochondria dysfunction in these epidemics. New strategies targeting adipocyte mitochondria from WAT and BAT are also discussed as therapies against obesity and its complications in next future.es
dc.language.isoenges
dc.publisherElsevieres
dc.relationS2010/BMD-2423
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectBioquímicaes
dc.subjectmitochondriaes
dc.subjectwhite adipose tissuees
dc.subjectbrown adipose tissuees
dc.subjectobesityes
dc.subjecttype 2 diabeteses
dc.subjectlipotoxicityes
dc.subjectreactive oxygen specieses
dc.subjectbeta-oxidationes
dc.titleMitochondria and endocrine function of adipose tissuees
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.1016/j.beem.2012.06.002es
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.subject.unesco3205.02 Endocrinologíaes
dc.description.departamentoBioquímica, Fisiología y Genética Molecular


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