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Involvement of protein tyrosine phosphatases and inflammation in hypothalamus insulin resistance associated with ageing: effect of caloric restriction

dc.contributor.authorGarcía-San Frutos, Miriam
dc.contributor.authorFernández-Agulló, Teresa
dc.contributor.authorCarrascosa, Jose María
dc.contributor.authorHorrillo, Daniel
dc.contributor.authorBarrús, María Teresa
dc.contributor.authorOliveros, Eva
dc.contributor.authorSierra, Johanna
dc.contributor.authorRos, Manuel
dc.identifier.citationInvolvement of protein tyrosine phosphatases and inflammation in hypothalamic insulin resistance associated with ageing: Effect of caloric restriction Garcia-San Frutos M., Fernandez-Agullo T., Carrascosa J.M., Horrillo D., Barrus M.T., Oliveros E., Sierra J., Ros M. (2012) Mechanisms of Ageing and Development, 133 (7) , pp. 489-497.
dc.description.abstractAged Wistar rats present central insulin resistance associated with ageing. Several steps of the insulin signaling pathway have been described to be impaired in aged rats at hypothalamic level. In the present article we have explored possible alterations in protein tyrosine phosphatases (PTPs) involved in insulin receptor dephosphorylation, as well as pro-inflammatory pathways and serine kinases such as inhibitory kappa ß kinase-nuclear factor kappa-B (IKKß-NF¿B), p38 mitogen-activated protein kinase (p38) and protein kinase C ¿ (PKC¿) that may also be involved in insulin signaling decrease during ageing. We detected that ageing brings about a specific increase in insulin receptor PTP activity and PTP1B serine phosphorylation. Increased association of PTP1B and leukocyte common antigen-related tyrosine protein phosphatase (LAR) with insulin receptor was also observed in hypothalamus from aged rats. Besides these mechanisms, increased activation of the IKKß-NF¿B pathway, p38 and PKC¿ serine/threonine kinases were also detected. These data contribute to explain the hypothalamic insulin resistance associated with ageing. Caloric restriction ameliorates most of the effects of ageing on the above mentioned increases in PTPs and serine/threonine kinases activities and points to age-associated adiposity and inflammation as key factors in the development of age-associated insulin
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España
dc.subjectInsulin resistancees
dc.subjectcaloric restrictiones
dc.titleInvolvement of protein tyrosine phosphatases and inflammation in hypothalamus insulin resistance associated with ageing: effect of caloric restrictiones
dc.subject.unesco3205.02 Endocrinologíaes
dc.description.departamentoBioquímica, Fisiología y Genética Molecular

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