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Effects of two different acute and subchronic stressors on gastrointestinal transit in the rat: A radiographic analysis

dc.contributor.authorBagues, Ana
dc.contributor.authorLopez-Tofiño, Yolanda
dc.contributor.authorGalvez-Robleño, Carlos
dc.contributor.authorAbalo, Raquel
dc.date.accessioned2022-02-07T17:48:38Z
dc.date.available2022-02-07T17:48:38Z
dc.date.issued2021
dc.identifier.citationBagues A, Lopez-Tofiño Y, Galvez-Robleño C, Abalo R. Effects of two different acute and subchronic stressors on gastrointestinal transit in the rat: A radiographic analysis. Neurogastroenterol Motil. 2021 Nov;33(11):e14232. doi: 10.1111/nmo.14232. Epub 2021 Aug 11. PMID: 34378822.es
dc.identifier.urihttp://hdl.handle.net/10115/18591
dc.description.abstractBackground: The reaction to stress is an adaptive response necessary for survival. When stressors are repeated, the organism adapts, although these adaptive responses can become dysregulated and result in disease, causing gastrointestinal (GI) disorders. Radiographic methods allow the non-invasive study of how a given factor affects GI transit in the same animal at different time points. These methods have never been applied to study the consequences of stress on GI motor function and their dependency on time and stimulus. Therefore, our aim was to characterize, using radiographic techniques, the effect on GI transit of cold-restraint (CR) and forced swim (FS) stress applied acutely and subchronically in the rat. Methods: Male Wistar rats (260–330 g) were submitted to FS or CR stress, during 1 (acute) or 4 (subchronic) consecutive days. To study GI transit, radiographic methods were used. Radiographs were taken 0–24 h after barium intragastric administration on the 1st or 4th day of stress, which was applied 1 h after contrast. Results: Acute FS or CR slowed down gastric and small intestinal emptying but had opposite effects in the caecum: CR tended to accelerate barium transit and feces formation while FS tended to slow these parameters down. When the stimuli were applied subchronically, GI transit was not completely normalized in most of the studied parameters. Conclusion and Inferences: Mild stress alters GI transit differently depending on the nature of the stressor and its duration. Exposure to mild stressors should be considered as contributing factors to different functional GI disorders.es
dc.description.sponsorshipUniversidad Rey Juan Carlos (GrantNumber(s): PREDOC20-054; Grant recipient(s): Carlos Gálvez-Robleño, Yolanda López-Tofiño) Consejería de Educación, Juventud y Deporte, Comunidad de Madrid (GrantNumber(s): PEJD-2017-PRE/BMD-3924; Grant recipient(s): Yolanda López-Tofiño) Ministerio de Ciencia, Innovación y Universidades (GrantNumber(s): PID2019-111510RB-I00; Grant recipient(s): R ABALO)es
dc.language.isoenges
dc.publisherWileyes
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectcold restraintes
dc.subjectforced swim stresses
dc.subjectgastrointestinal transites
dc.subjectradiographic analysises
dc.subjectrates
dc.subjectstresses
dc.subjectstress adaptationes
dc.titleEffects of two different acute and subchronic stressors on gastrointestinal transit in the rat: A radiographic analysises
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.1111/nmo.14232es
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses


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Attribution-NonCommercial-NoDerivatives 4.0 InternacionalExcept where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional