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Human intestinal pro-inflammatory CD11chighCCR2+CX3CR1+ macrophages, but not their tolerogenic CD11c−CCR2−CX3CR1− counterparts, are expanded in inflammatory bowel disease

dc.contributor.authorBernardo, David
dc.contributor.authorMarin, Alicia C
dc.contributor.authorFernández-Tomé, Samuel
dc.contributor.authorMontalban-Arqués, Ana
dc.contributor.authorCarrasco, A
dc.contributor.authorTristan, E
dc.contributor.authorOrtega Moreno, Lorena
dc.contributor.authorMora-Gutierrez, Irene
dc.contributor.authorDiaz-Guerra, A
dc.contributor.authorCaminero-Fernández, R
dc.contributor.authorMiranda, P
dc.contributor.authorCasals, F
dc.contributor.authorCaldas, M
dc.contributor.authorJiménez, M
dc.contributor.authorCasabona, Sergio
dc.contributor.authorde la Morena, F
dc.contributor.authorEsteve, M
dc.contributor.authorSantander, Cecilio
dc.contributor.authorChaparro, María
dc.contributor.authorGisbert, Javier P.
dc.date.accessioned2023-11-30T16:33:19Z
dc.date.available2023-11-30T16:33:19Z
dc.date.issued2018
dc.identifier.citationBernardo, D., Marin, A.C., Fernández-Tomé, S. et al. Human intestinal pro-inflammatory CD11chighCCR2+CX3CR1+ macrophages, but not their tolerogenic CD11c−CCR2−CX3CR1− counterparts, are expanded in inflammatory bowel disease. Mucosal Immunol 11, 1114–1126 (2018). https://doi.org/10.1038/s41385-018-0030-7
dc.identifier.issn1114–1126
dc.identifier.urihttps://hdl.handle.net/10115/26777
dc.description.abstractAlthough macrophages (Mϕ) maintain intestinal immune homoeostasis, there is not much available information about their subset composition, phenotype and function in the human setting. Human intestinal Mϕ (CD45+HLA-DR+CD14+CD64+) can be divided into subsets based on the expression of CD11c, CCR2 and CX3CR1. Monocyte-like cells can be identified as CD11chighCCR2+CX3CR1+ cells, a phenotype also shared by circulating CD14+ monocytes. On the contrary, their Mϕ-like tissue-resident counterparts display a CD11c−CCR2−CX3CR1− phenotype. CD11chigh monocyte-like cells produced IL-1β, both in resting conditions and after LPS stimulation, while CD11c− Mϕ-like cells produced IL-10. CD11chigh pro-inflammatory monocyte-like cells, but not the others, were increased in the inflamed colon from patients with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Tolerogenic IL-10-producing CD11c− Mϕ-like cells were generated from monocytes following mucosal conditioning. Finally, the colonic mucosa recruited circulating CD14+ monocytes in a CCR2-dependent manner, being such capacity expanded in IBD. Mϕ subsets represent, therefore, transition stages from newly arrived pro-inflammatory monocyte-like cells (CD11chighCCR2+CX3CR1+) into tolerogenic tissue-resident (CD11c−CCR2−CX3CR1−) Mϕ-like cells as reflected by the mucosal capacity to recruit circulating monocytes and induce CD11c− Mϕ. The process is nevertheless dysregulated in IBD, where there is an increased migration and accumulation of pro-inflammatory CD11chigh monocyte-like cells.es
dc.publisherSpringer Naturees
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleHuman intestinal pro-inflammatory CD11chighCCR2+CX3CR1+ macrophages, but not their tolerogenic CD11c−CCR2−CX3CR1− counterparts, are expanded in inflammatory bowel diseasees
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.1038/s41385-018-0030-7es
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
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Attribution 4.0 InternationalExcept where otherwise noted, this item's license is described as Attribution 4.0 International