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Miniaturized Analytical Strategy Based on μ‑SPEed for Monitoring the Occurrence of Pyrrolizidine and Tropane Alkaloids in Honey

dc.contributor.authorCasado, Natalia
dc.contributor.authorMorante-Zarcero, Sonia
dc.contributor.authorSierra, Isabel
dc.date.accessioned2024-01-19T17:57:58Z
dc.date.available2024-01-19T17:57:58Z
dc.date.issued2023-12-18
dc.identifier.citationCasado, N., Morante-Zarcero, S., & Sierra, I. (2024). Miniaturized Analytical Strategy Based on μ-SPEed for Monitoring the Occurrence of Pyrrolizidine and Tropane Alkaloids in Honey. Journal of Agricultural and Food Chemistry, 72(1), 819-832. 10.1021/acs.jafc.3c04805es
dc.identifier.issn0021-8561
dc.identifier.urihttps://hdl.handle.net/10115/28600
dc.descriptionThis research was funded by MCIU/AEI/FEDER, UE, project number RTI2018-094558-B-I00and by the call Proyectos de Impulso a la Investigación para Jóvenes Doctores de la Universidad Rey Juan Carlos, project PROCESALK ref. M2984.es
dc.description.abstractCurrently, the analysis of trace-level contaminants in food must be addressed following the Green Analytical Chemistry principles and with the commitment to the Sustainable Development Goals. Accordingly, a sustainable and ecofriendly microextraction procedure based on µ-SPEed® followed by ultra-high liquid chromatography coupled to ion-trap tandem mass spectrometry analysis was developed to determine the occurrence of pyrrolizidine and tropane alkaloids in honey samples. The µ-SPEed® procedure took approximately 3 min per sample, using only 100 μL of organic solvent and 300 μL of diluted sample. The method was properly validated (overall recoveries 72-100% and precision RSD values ≤15%) and its greenness was scored at 0.61 out of 1. The method was applied to different honey samples, showing overall contamination levels from 32 to 177 µg/kg of these alkaloids. Atropine was found in all the samples, whereas retrorsine N-oxide, lasiocarpine, echimidine and echimidine N-oxide were the main pyrrolizidine alkaloids in the samples analyzed.es
dc.language.isoenges
dc.publisherAmerican Chemical Societyes
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectNatural toxinses
dc.subjectalkaloidses
dc.subjectGreen analytical chemistryes
dc.subjectMicroextractiones
dc.subjectUHPLC-IT-MS/MSes
dc.subjectFood safetyes
dc.titleMiniaturized Analytical Strategy Based on μ‑SPEed for Monitoring the Occurrence of Pyrrolizidine and Tropane Alkaloids in Honeyes
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.1021/acs.jafc.3c04805es
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses


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Atribución 4.0 InternacionalExcept where otherwise noted, this item's license is described as Atribución 4.0 Internacional