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From obesity to diabetes and cancer: epidemiological links and role of therapies

dc.contributor.authorGarcía-Jiménez, Custodia
dc.contributor.authorGutiérrez-Salmerón, María
dc.contributor.authorChocarro-Calvo, Ana
dc.contributor.authorGarcía-Martinez, José Manuel
dc.contributor.authorCastaño, Angel
dc.contributor.authorDe la Vieja, Antonio
dc.date.accessioned2024-01-26T08:44:44Z
dc.date.available2024-01-26T08:44:44Z
dc.date.issued2016-02-23
dc.identifier.citationBr J Cancer 114, 716–722 (2016)es
dc.identifier.issn0007-0920
dc.identifier.urihttps://hdl.handle.net/10115/28947
dc.description.abstractIncreasing evidence suggests a complex relationship between obesity, diabetes and cancer. Here we review the evidence for the association between obesity and diabetes and a wide range of cancer types. In many cases the evidence for a positive association is strong, but for other cancer types a more complex picture emerges with some site-specific cancers associated with obesity but not to diabetes, and some associated with type I but not type II diabetes. The evidence therefore suggests the existence of cumulative common and differential mechanisms influencing the relationship between these diseases. Importantly, we highlight the influence of antidiabetics on cancer and antineoplastic agents on diabetes and in particular that antineoplastic targeting of insulin/IGF-1 signalling induces hyperglycaemia that often evolves to overt diabetes. Overall, a coincidence of diabetes and cancer worsens outcome and increases mortality. Future epidemiology should consider dose and time of exposure to both disease and treatment, and should classify cancers by their molecular signatures. Well-controlled studies on the development of diabetes upon cancer treatment are necessary and should identify the underlying mechanisms responsible for these reciprocal interactions. Given the global epidemic of diabetes, preventing both cancer occurrence in diabetics and the onset of diabetes in cancer patients will translate into a substantial socioeconomic benefit.es
dc.language.isoenges
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectdiabeteses
dc.subjectobesityes
dc.subjectcanceres
dc.subjectantidiabetic treatmentes
dc.subjectantineoplastic therapyes
dc.subjectinsulines
dc.titleFrom obesity to diabetes and cancer: epidemiological links and role of therapieses
dc.typeinfo:eu-repo/semantics/reviewes
dc.identifier.doi10.1038/bjc.2016.37es
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses


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