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Iron supplementation in mouse expands cellular innate defences in spleen and defers lethal malaria infection.Iron supplementation in mouse expands cellular innate defences in spleen and defers lethal malaria infection.

dc.contributor.authorAzcárate, Isabel G.
dc.contributor.authorSánchez-Jaut, Sandra
dc.contributor.authorMarín-García, Patricia
dc.contributor.authorLinares, María
dc.contributor.authorPérez-Benavente, Susana
dc.contributor.authorGarcía-Sánchez, Marta
dc.contributor.authorUceda, Javier
dc.contributor.authorKamali, Ali N.
dc.contributor.authorMorán-Jiménez, María-Josefa
dc.contributor.authorPuyet, Antonio
dc.contributor.authorDiez, Amalia
dc.contributor.authorBautista, José M.
dc.date.accessioned2024-01-31T11:50:27Z
dc.date.available2024-01-31T11:50:27Z
dc.date.issued2017-09-29
dc.identifier.citationAzcárate IG, Sánchez-Jaut S, Marín-García P, Linares M, Pérez-Benavente S, García-Sánchez M, Uceda J, Kamali AN, Morán-Jiménez MJ, Puyet A, Diez A, Bautista JM. Iron supplementation in mouse expands cellular innate defences in spleen and defers lethal malaria infection. Biochim Biophys Acta Mol Basis Dis. 2017 Dec;1863(12):3049-3059. doi: 10.1016/j.bbadis.2017.09.027. Epub 2017 Sep 29. PMID: 28965885.es
dc.identifier.issn0925-4439
dc.identifier.urihttps://hdl.handle.net/10115/29349
dc.description.abstractThe co-endemicity of malnutrition, erythrocytopathies, transmissible diseases and iron-deficiency contribute to the prevalence of chronic anaemia in many populations of the developing world. Although iron dietary supplementation is applied or recommended in at risk populations, its use is controversial due to undesirable outcomes, particularly regarding the response to infections, including highly prevalent malaria. We hypothesized that a boosted oxidative stress due to iron supplementation have a similar impact on malaria to that of hereditary anaemias, enhancing innate response and conditioning tissues to prevent damage during infection. Thus, we have analysed antioxidant and innate responses against lethal Plasmodium yoelii during the first five days of infection in an iron-supplemented mouse. This murine model showed high iron concentration in plasma with upregulated expression of hemoxygenase-1. The sustained homeostasis after this extrinsic iron conditioning, delayed parasitemia growth that, once installed, developed without anaemia. This protection was not conferred by the intrinsic iron overload of hereditary hemochromatosis. Upon iron-supplementation, a large increase of the macrophages/dendritic cells ratio and the antigen presenting cells was observed in the mouse spleen, independently of malaria infection. Complementary, malaria promoted the splenic B and T CD4 cells activation. Our results show that the iron supplementation in mice prepares host tissues for oxidative-stress and induces unspecific cellular immune responses, which could be seen as an advantage to promote early defences against malaria infection.es
dc.language.isoenges
dc.publisherBiochimica et Biophysica Acta (BBA) - Molecular Basis of Diseasees
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectIron supplementationes
dc.subjectOxidative stresses
dc.subjectMalariaes
dc.subjectImmune responsees
dc.subjectHemochromatosises
dc.titleIron supplementation in mouse expands cellular innate defences in spleen and defers lethal malaria infection.Iron supplementation in mouse expands cellular innate defences in spleen and defers lethal malaria infection.es
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.1016/j.bbadis.2017.09.027es
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses


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Atribución 4.0 InternacionalExcept where otherwise noted, this item's license is described as Atribución 4.0 Internacional