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Two-photon activated precision molecular photosensitizer targeting mitochondria

dc.contributor.authorSantiago, Ana M.
dc.contributor.authorMariz, Inês F. A.
dc.contributor.authorPinto, Sandra N.
dc.contributor.authorMartinho, José M. G.
dc.contributor.authorRecio, Javier
dc.contributor.authorVaquero, Juan J.
dc.contributor.authorCuadro, Ana M.
dc.contributor.authorMaçôas, Ermelinda
dc.date.accessioned2024-01-31T16:36:14Z
dc.date.available2024-01-31T16:36:14Z
dc.date.issued2021-10-07
dc.identifier.citationMariz, I.F.A., Pinto, S.N., Santiago, A.M. et al. Two-photon activated precision molecular photosensitizer targeting mitochondria. Commun Chem 4, 142 (2021). https://doi.org/10.1038/s42004-021-00581-4es
dc.identifier.issn2399-3669
dc.identifier.urihttps://hdl.handle.net/10115/29374
dc.description.abstractMitochondria metabolism is an emergent target for the development of novel anticancer agents. It is amply recognized that strategies that allow for modulation of mitochondrial function in specific cell populations need to be developed for the therapeutic potential of mitochondria-targeting agents to become a reality in the clinic. In this work, we report dipolar and quadrupolar quinolizinium and benzimidazolium cations that show mitochondria targeting ability and localized light-induced mitochondria damage in live animal cells. Some of the dyes induce a very efficient disruption of mitochondrial potential and subsequent cell death under two-photon excitation in the Near-infrared (NIR) opening up possible applications of azonia/azolium aromatic heterocycles as precision photosensitizers. The dipolar compounds could be excited in the NIR due to a high two-photon brightness while exhibiting emission in the red part of the visible spectra (600–700 nm). Interaction with the mitochondria leads to an unexpected blue-shift of the emission of the far-red emitting compounds, which we assign to emission from the locally excited state. Interaction and possibly aggregation at the mitochondria prevents access to the intramolecular charge transfer state responsible for far-red emission.es
dc.language.isoenges
dc.publisherNature Researches
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectNonlinear-optical propertieses
dc.subjectFluorescent-probeses
dc.subjectSinglet oxygenes
dc.subjectPhotodynamic therapyes
dc.subjectNIR Photosensitizeres
dc.subjectQuinolizinium dyeses
dc.subjectNanoparticleses
dc.subjectQuantum Dotses
dc.titleTwo-photon activated precision molecular photosensitizer targeting mitochondriaes
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.1038/s42004-021-00581-4es
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses


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Atribución 4.0 InternacionalExcept where otherwise noted, this item's license is described as Atribución 4.0 Internacional