dc.contributor.author | Santiago, Ana M. | |
dc.contributor.author | Mariz, Inês F. A. | |
dc.contributor.author | Pinto, Sandra N. | |
dc.contributor.author | Martinho, José M. G. | |
dc.contributor.author | Recio, Javier | |
dc.contributor.author | Vaquero, Juan J. | |
dc.contributor.author | Cuadro, Ana M. | |
dc.contributor.author | Maçôas, Ermelinda | |
dc.date.accessioned | 2024-01-31T16:36:14Z | |
dc.date.available | 2024-01-31T16:36:14Z | |
dc.date.issued | 2021-10-07 | |
dc.identifier.citation | Mariz, I.F.A., Pinto, S.N., Santiago, A.M. et al. Two-photon activated precision molecular photosensitizer targeting mitochondria. Commun Chem 4, 142 (2021). https://doi.org/10.1038/s42004-021-00581-4 | es |
dc.identifier.issn | 2399-3669 | |
dc.identifier.uri | https://hdl.handle.net/10115/29374 | |
dc.description.abstract | Mitochondria metabolism is an emergent target for the development of novel anticancer
agents. It is amply recognized that strategies that allow for modulation of mitochondrial
function in specific cell populations need to be developed for the therapeutic potential of
mitochondria-targeting agents to become a reality in the clinic. In this work, we report dipolar
and quadrupolar quinolizinium and benzimidazolium cations that show mitochondria targeting
ability and localized light-induced mitochondria damage in live animal cells. Some of
the dyes induce a very efficient disruption of mitochondrial potential and subsequent cell
death under two-photon excitation in the Near-infrared (NIR) opening up possible applications
of azonia/azolium aromatic heterocycles as precision photosensitizers. The dipolar
compounds could be excited in the NIR due to a high two-photon brightness while exhibiting
emission in the red part of the visible spectra (600–700 nm). Interaction with the mitochondria
leads to an unexpected blue-shift of the emission of the far-red emitting compounds,
which we assign to emission from the locally excited state. Interaction and possibly
aggregation at the mitochondria prevents access to the intramolecular charge transfer state
responsible for far-red emission. | es |
dc.language.iso | eng | es |
dc.publisher | Nature Research | es |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Nonlinear-optical properties | es |
dc.subject | Fluorescent-probes | es |
dc.subject | Singlet oxygen | es |
dc.subject | Photodynamic therapy | es |
dc.subject | NIR Photosensitizer | es |
dc.subject | Quinolizinium dyes | es |
dc.subject | Nanoparticles | es |
dc.subject | Quantum Dots | es |
dc.title | Two-photon activated precision molecular photosensitizer targeting mitochondria | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | 10.1038/s42004-021-00581-4 | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |