Highly Stable Double‐Stranded DNA Containing Sequential Silver (I)‐Mediated 7‐Deazaadenine/Thymine Watson–Crick Base Pairs
dc.contributor.author | Santamaría‐Díaz, Noelia | |
dc.contributor.author | Mendez‐Arriaga, Jose Manuel | |
dc.contributor.author | Salas, Juan Manuel | |
dc.contributor.author | Galindo, Miguel A | |
dc.date.accessioned | 2024-02-07T11:05:50Z | |
dc.date.available | 2024-02-07T11:05:50Z | |
dc.date.issued | 2016-05-17 | |
dc.identifier.citation | Angew. Chem. Int. Ed. 2016, 55, 6170 –6174 | es |
dc.identifier.issn | 1433-7851 | |
dc.identifier.issn | 1521-3773 | |
dc.identifier.uri | https://hdl.handle.net/10115/29872 | |
dc.description.abstract | The oligonucleotide d(TX)9, which consists of an octadecamer sequence with alternating non-canonical 7-deazaadenine (X) and canonical thymine (T) as the nucleobases, was synthesized and shown to hybridize into double-stranded DNA through the formation of hydrogen-bonded Watson–Crick base pairs. dsDNA with metal-mediated base pairs was then obtained by selectively replacing W-C hydrogen bonds by coordination bonds to central silver(I) ions. The oligonucleotide I adopts a duplex structure in the absence of Ag+ ions, and its stability is significantly enhanced in the presence of Ag+ ions while its double-helix structure is retained. Temperature-dependent UV spectroscopy, circular dichroism spectroscopy, and ESI mass spectrometry were used to confirm the selective formation of the silver(I)-mediated base pairs. This strategy could become useful for preparing stable metallo-DNA-based nanostructures. | es |
dc.language.iso | eng | es |
dc.publisher | Wiley | es |
dc.title | Highly Stable Double‐Stranded DNA Containing Sequential Silver (I)‐Mediated 7‐Deazaadenine/Thymine Watson–Crick Base Pairs | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | 10.1002/anie.201600924 | es |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | es |
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