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Mitochondrial ROS production, oxidative stress and aging within and between species: Evidences and recent advances on this aging effector

dc.contributor.authorGómez, José
dc.contributor.authorMota-Martorell, Natália
dc.contributor.authorJové, Mariona
dc.contributor.authorPamplona, Reinald
dc.contributor.authorBarja, Gustavo
dc.date.accessioned2024-02-21T15:56:53Z
dc.date.available2024-02-21T15:56:53Z
dc.date.issued2023-02-27
dc.identifier.citationJosé Gómez, Natàlia Mota-Martorell, Mariona Jové, Reinald Pamplona, Gustavo Barja, Mitochondrial ROS production, oxidative stress and aging within and between species: Evidences and recent advances on this aging effector, Experimental Gerontology, Volume 174, 2023, 112134, ISSN 0531-5565, https://doi.org/10.1016/j.exger.2023.112134.es
dc.identifier.issn1873-6815
dc.identifier.urihttps://hdl.handle.net/10115/30586
dc.description.abstractMitochondria play a wide diversity of roles in cell physiology and have a key functional implication in cell bioenergetics and biology of free radicals. As the main cellular source of oxygen radicals, mitochondria have been postulated as the mediators of the cellular decline associated with the biological aging. Recent evidences have shown that mitochondrial free radical production is a highly regulated mechanism contributing to the biological determination of longevity which is species-specific. This mitochondrial free radical generation rate induces a diversity of adaptive responses and derived molecular damage to cell components, highlighting mitochondrial DNA damage, with biological consequences that influence the rate of aging of a given animal species. In this review, we explore the idea that mitochondria play a fundamental role in the determination of animal longevity. Once the basic mechanisms are discerned, molecular approaches to counter aging may be designed and developed to prevent or reverse functional decline, and to modify longevity.es
dc.language.isoenges
dc.publisherElsevieres
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAnimal longevityes
dc.subjectComplex Ies
dc.subjectDNA damagees
dc.subjectDNA fragmentses
dc.subjectElectron transport chaines
dc.subjectNDUFV2 subunites
dc.subjectFeS N1a iron-sulfur clusteres
dc.subjectAging ratees
dc.titleMitochondrial ROS production, oxidative stress and aging within and between species: Evidences and recent advances on this aging effectores
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.1016/j.exger.2023.112134es
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses


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Attribution-NonCommercial-NoDerivatives 4.0 InternacionalExcept where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional