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Programmed versus non-programmed evolution of aging. What is the evidence?

dc.contributor.authorPamplona, Reinald
dc.contributor.authorJové, Mariona
dc.contributor.authorGómez, José
dc.contributor.authorBarja, Gustavo
dc.date.accessioned2024-02-21T15:58:24Z
dc.date.available2024-02-21T15:58:24Z
dc.date.issued2023-04-05
dc.identifier.citationReinald Pamplona, Mariona Jové, José Gómez, Gustavo Barja, Programmed versus non-programmed evolution of aging. What is the evidence?, Experimental Gerontology, Volume 175, 2023, 112162, ISSN 0531-5565, https://doi.org/10.1016/j.exger.2023.112162.es
dc.identifier.issn1873-6815
dc.identifier.issn1873-6815
dc.identifier.urihttps://hdl.handle.net/10115/30589
dc.description.abstractThe evolutionary meaning and basic molecular mechanisms involved in the determination of longevity remain an unresolved problem. Currently, different theories are on offer in response to these biological traits and to explain the enormous range of longevities observed in the animal kingdom. These theories may be grouped into those that defend non-programmed aging (non-PA) and those that propose the existence of programmed aging (PA). In the present article we examine many observational and experimental data from both the field and from the laboratory and sound reasoning accumulated in recent decades both compatible and not with PA and non-PA evolutionary theories of aging. These analyses are briefly summarized and discussed. Our conclusion is that most of the data favour programmed aging with a possible contribution of non-PA antagonist pleiotropy in various cases.es
dc.language.isoenges
dc.publisherElsevieres
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectRate of aginges
dc.subjectSignalling pathwayses
dc.subjectMetabolic phenotypeses
dc.subjectEvolutiones
dc.subjectPro-longevity dietary interventionses
dc.subjectAnimal longevityes
dc.titleProgrammed versus non-programmed evolution of aging. What is the evidence?es
dc.typeinfo:eu-repo/semantics/reviewes
dc.identifier.doi10.1016/j.exger.2023.112162es
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses


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Attribution-NonCommercial-NoDerivatives 4.0 InternacionalExcept where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional