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Characterization of a human Bid homologue protein from Gallus gallus

dc.contributor.authorDíaz-Gil, Gema
dc.contributor.authorGómez-Esquer, Francisco
dc.contributor.authorAgudo, David
dc.contributor.authorDelcán, Jose
dc.contributor.authorMartínez-Arribas, Fernando
dc.contributor.authorRivas, Carmen
dc.contributor.authorSchneider, José
dc.contributor.authorPalomar, Ma Angustias
dc.contributor.authorLinares, Rafael
dc.date.accessioned2010-02-15T13:00:32Z
dc.date.available2010-02-15T13:00:32Z
dc.date.issued2006
dc.identifier.urihttp://hdl.handle.net/10115/3255
dc.description.abstractBid protein, a member of the "BH3-only" subgroup of Bcl-2 family, plays a critical role in mammalian apoptosis regulation. In this study, we have cloned the chicken Bid gene, which encodes a 193 amino acid protein and shares 40% homology with human and mouse Bid proteins. Bid sequence comparison emphasises the conservation of both the functional domain BH3 and the proteolytic cleavage sites. An induction of apoptosis by chicken Bid and the cleavage of the protein, after TNF treatment, were also demonstrated. In addition, mRNA Bid expression was detected along all embryo stages and tissues examined, suggesting a role for this protein in the developmental process. This is the first report demonstrating the functionality of a "BH3-only" protein in chicken.es
dc.language.isoenes
dc.publisherGene Section Functional Genomicses
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectGenéticaes
dc.titleCharacterization of a human Bid homologue protein from Gallus galluses
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.1016/j.gene.2005.12.011es
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.subject.unesco2409 Genéticaes
dc.description.departamentoEstomatología


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