Show simple item record

Enhanced Cytotoxicity and Reactivity of a Novel Platinum(IV) Family with DNA-Targeting Naphthalimide Ligands

dc.contributor.authorNavas, Francisco
dc.contributor.authorMendes, Filipa
dc.contributor.authorSantos, Isabel
dc.contributor.authorNavarro-Ranninger, Carmen
dc.contributor.authorCabrera, Silvia
dc.contributor.authorGómez Quiroga, Adoración
dc.date.accessioned2024-05-22T06:41:17Z
dc.date.available2024-05-22T06:41:17Z
dc.date.issued2017-05-10
dc.identifier.citationFrancisco Navas, Filipa Mendes, Isabel Santos, Carmen Navarro-Ranninger, Silvia Cabrera, Adoración G. Quiroga. Inorganic Chemistry, 2017, 56, 6175-6183.es
dc.identifier.issn0020-1669
dc.identifier.urihttps://hdl.handle.net/10115/33031
dc.descriptionEste artículo describe la síntesis y caracterización de una familia de complejos de Pt(IV) con ligandos naftalimida como profármacos antitumorales y la evaluación de su actividad anticancerígena in vitro.es
dc.description.abstractPt(IV) complexes are known as prodrugs that can potentially overcome cisplatin limitations by slowing down its reactivity, and once reduced, act as the corresponding Pt(II) drugs. We report a new approach towards trans Pt(IV) complexes, conceived to afford nonconventional active trans Pt(II) complexes with dual targeting properties. The reduction of the complexes has been studied in the presence of ascorbic acid and glutathione, showing that different species are formed in the process. The interaction with DNA after reduction has been also studied and correlated to the formation of Pt(II) species. The cytotoxicity profile of the Pt(IV) complexes corroborated the rationale behind this approach.es
dc.language.isoenges
dc.publisherAmerican Chemical Societyes
dc.rightsAttribution-NonCommercial-NoDerivs 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectPt(IV) complexes, biological reductants, cytotoxicity, DNA interaction.es
dc.titleEnhanced Cytotoxicity and Reactivity of a Novel Platinum(IV) Family with DNA-Targeting Naphthalimide Ligandses
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.1021/acs.inorgchem.7b00136es
dc.rights.accessRightsinfo:eu-repo/semantics/OpenAccesses


Files in this item

Name:
Versión aceptada Pt(IV)-naftal ...
Size:
1.515Mb
Format:
PDF
View/Open

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 4.0 InternationalExcept where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 4.0 International