Plasma D-dimer value corrected by inflammatory markers in patients with SARS-CoV-2 infection: Its prognostic value in the diagnosis of venous thromboembolism.
dc.contributor.author | Rueda-Camino, Jose Antonio | |
dc.contributor.author | Sendin Martín, Vanesa | |
dc.contributor.author | Joya Seijo, Maria Dolores | |
dc.contributor.author | Angelina García, María | |
dc.contributor.author | Zamarro García, Celia | |
dc.contributor.author | Gimena Rodriguez, Francisco Javier | |
dc.contributor.author | Barba Martín, Raquel | |
dc.date.accessioned | 2024-10-30T16:09:46Z | |
dc.date.available | 2024-10-30T16:09:46Z | |
dc.date.issued | 2021-06 | |
dc.identifier.citation | Rueda-Camino JA, Sendín-Martín V, Joya-Seijo MD, Angelina-García M, Zamarro- García C, Gimena-Rodríguez FJ, Barba-Martín R. Plasma D-dimer value corrected by inflammatory markers in patients with SARS-CoV-2 infection: Its prognostic value in the diagnosis of venous thromboembolism. Med Clin (Barc). 2021 Jun 3:S0025-7753(21)00253-0 | es |
dc.identifier.issn | 0025-7753 (print) | |
dc.identifier.issn | 1578-8989 (online) | |
dc.identifier.uri | https://hdl.handle.net/10115/40901 | |
dc.description.abstract | Introduction: D-dimer levels are elevated in COVID 19 and they correlate to the levels of other inflammatory markers such us ferritin, fibrinogen and C-reactive protein. It may be possible to correct D-dimer value in function of inflammatory markers, thus identifying patients at higher risk of venous thromboembolism (VTE). Our objectives are estimating a corrected value of plasma D-dimer as a linear function of ferritin, C-reactive protein and fibrinogen and stablishing a cut-off point of high probability of VTE. Patients and methods: Age and sex matched case-control study of all patients diagnosed with COVID 19 and VTE between March and May 2020 in a tertiary hospital in Madrid (Spain). Using linear regression, the best predictive model will be estimated and residual D-dimer values will be obtained and analyzed using ROC curves to determine its discriminative performance. Results: Thirty-eight cases and seventy-six controls were included. There was 63.2% of men and mean age was 68.2. D-dimer was best predicted by a linear model including fibrinogen, ferritin and C-reactive protein. Using residual values, the optimal cutoff point was 2165ng/mL, with a sensitivity of 57.9% and specificity of 98.7%. Conclusion: It is possible to estimate a D-dimer corrected value in function of ferritin, C-reactive protein and fibrinogen. Using the observed and estimated value we can obtain a residual value that performs well as a screening method to detect patients who would benefit for further VTE diagnostic testing. | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.subject | Acute-phase proteins | es |
dc.subject | Coronavirus disease 2019 | es |
dc.subject | Covid-19 | es |
dc.subject | Diagnosis | es |
dc.subject | Fibrin fragment d; | es |
dc.subject | Prediction | es |
dc.subject | Venous thromboembolism | es |
dc.title | Plasma D-dimer value corrected by inflammatory markers in patients with SARS-CoV-2 infection: Its prognostic value in the diagnosis of venous thromboembolism. | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | 10.1016/j.medcli.2021.03.034 | es |
dc.rights.accessRights | info:eu-repo/semantics/closedAccess | es |
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