Enhanced Cytotoxicity and Reactivity of a Novel Platinum(IV) Family with DNA-Targeting Naphthalimide Ligands

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dc.contributor.authorNavas, Francisco
dc.contributor.authorMendes, Filipa
dc.contributor.authorSantos, Isabel
dc.contributor.authorNavarro-Ranninger, Carmen
dc.contributor.authorCabrera, Silvia
dc.contributor.authorGómez Quiroga, Adoración
dc.date.accessioned2024-05-22T06:41:17Z
dc.date.available2024-05-22T06:41:17Z
dc.date.issued2017-05-10
dc.descriptionEste artículo describe la síntesis y caracterización de una familia de complejos de Pt(IV) con ligandos naftalimida como profármacos antitumorales y la evaluación de su actividad anticancerígena in vitro.es
dc.description.abstractPt(IV) complexes are known as prodrugs that can potentially overcome cisplatin limitations by slowing down its reactivity, and once reduced, act as the corresponding Pt(II) drugs. We report a new approach towards trans Pt(IV) complexes, conceived to afford nonconventional active trans Pt(II) complexes with dual targeting properties. The reduction of the complexes has been studied in the presence of ascorbic acid and glutathione, showing that different species are formed in the process. The interaction with DNA after reduction has been also studied and correlated to the formation of Pt(II) species. The cytotoxicity profile of the Pt(IV) complexes corroborated the rationale behind this approach.es
dc.identifier.citationFrancisco Navas, Filipa Mendes, Isabel Santos, Carmen Navarro-Ranninger, Silvia Cabrera, Adoración G. Quiroga. Inorganic Chemistry, 2017, 56, 6175-6183.es
dc.identifier.doi10.1021/acs.inorgchem.7b00136es
dc.identifier.issn0020-1669
dc.identifier.urihttps://hdl.handle.net/10115/33031
dc.language.isoenges
dc.publisherAmerican Chemical Societyes
dc.rightsAttribution-NonCommercial-NoDerivs 4.0 International
dc.rights.accessRightsinfo:eu-repo/semantics/OpenAccesses
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectPt(IV) complexes, biological reductants, cytotoxicity, DNA interaction.es
dc.titleEnhanced Cytotoxicity and Reactivity of a Novel Platinum(IV) Family with DNA-Targeting Naphthalimide Ligandses
dc.typeinfo:eu-repo/semantics/articlees

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