Insulin-like Growth Factor I Couples Metabolism with Circadian Activity through Hypothalamic Orexin Neurons

dc.contributor.authorPignatelli, jaime
dc.contributor.authorFernandez de sevilla, maria estrella
dc.contributor.authorSperbek, jacob
dc.contributor.authorHorrillo, Daniel
dc.contributor.authorMedina-gomez, Gema
dc.contributor.authorTorres Aleman, ignacio
dc.date.accessioned2024-01-25T05:42:47Z
dc.date.available2024-01-25T05:42:47Z
dc.date.issued2022-04-23
dc.description.abstractAbstract: Uncoupling of metabolism and circadian activity is associated with an increased risk of a wide spectrum of pathologies. Recently, insulin and the closely related insulin-like growth factor I (IGF-I) were shown to entrain feeding patterns with circadian rhythms. Both hormones act centrally to modulate peripheral glucose metabolism; however, whereas central targets of insulin actions are intensely scrutinized, those mediating the actions of IGF-I remain less defined. We recently showed that IGF-I targets orexin neurons in the lateral hypothalamus, and now we evaluated whether IGF-I modulates orexin neurons to align circadian rhythms with metabolism. Mice with disrupted IGF-IR activity in orexin neurons (Firoc mice) showed sexually dimorphic alterations in daily glucose rhythms and feeding activity patterns which preceded the appearance of metabolic disturbances. Thus, Firoc males developed hyperglycemia and glucose intolerance, while females developed obesity. Since IGF-I directly modulates orexin levels and hepatic expression of KLF genes involved in circadian and metabolic entrainment in an orexin-dependent manner, it seems that IGF-I entrains metabolism and circadian rhythms by modulating the activity of orexin neurons.es
dc.identifier.doi10.3390/ ijms23094679es
dc.identifier.issn1422-0067
dc.identifier.urihttps://hdl.handle.net/10115/28869
dc.language.isoenges
dc.publishermdpies
dc.rightsAtribución 4.0 Internacional*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectorexines
dc.subject; central control of metabolismes
dc.titleInsulin-like Growth Factor I Couples Metabolism with Circadian Activity through Hypothalamic Orexin Neuronses
dc.typeinfo:eu-repo/semantics/articlees

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