Different methods for the study of interactions of metal complexes with biological molecules

Abstract

In recent years, UV-visible has been used for the study of the interactions mainly with DNA (calculation of Kb) and also for qualitative information of the interactions with proteins and small molecules. In addition, NMR has been used for the study of the binding behaviour of some small molecules such as glutathione. Furthermore, cyclovoltammetric methods are becoming very interesting for medicinal chemists, due to the qualitative and quantitative informations about binding behaviour of metal complexes (with redox properties) and small and macrobiomolecules. This presentation contains a brief review of some methods for the study of the interaction of biomolecules with metal complexes.