Role of toll-like receptor 4 (TLR4) in two models of pain in rat

Abstract

According to the definition given by the International Association for the Study of Pain (IASP), pain is ¿an unpleasant sensory and emotional experience that is primarily associated with tissue damage or described in such terms¿ (Merskey, 1986). As inferred from the previous line, an unpleasant sensation confined to a definite anatomical area of the sufferer is not enough to categorize pain, but coexists with cognitive and emotional components that escape to the external observer¿s eye. That is, pain is a personal and subjective experience (Melzack and Katz, 2001).