Mesostructured Silica-Coated Magnetic Nanoparticles to Extract Six Opium Alkaloids in Poppy Seeds Prior to Ultra-High-Performance Liquid Chromatography-Tandem Mass Spectrometry Analysis
Archivos
Fecha
2021
Título de la revista
ISSN de la revista
Título del volumen
Editor
MDPI
Enlace externo
Resumen
In recent years, health authorities have become increasingly concerned about preventing
consumer exposure to opium alkaloids present in Papaver somniferum L. poppy seeds. In this
study, a simple, rapid and efficient method has been optimised to determine all main opioids
in poppy seeds (morphine, codeine, thebaine, papaverine, noscapine and oripavine) by UHPLCQqQ-
MS/MS. For this purpose, solid-liquid extraction (SLE) of samples was optimised and six
magnetic adsorbent materials with a core of Fe3O4 coated with amorphous and mesostructured
silica, both functionalised with octadecyl-silane or octyl-silane were characterised and evaluated for
magnetic solid-phase extraction (MSPE). The material with the best results was non-functionalised
mesostructured silica and, with it, the MSPE procedure was optimised. This method was validated
and used to quantify six opioids in 14 edible seed samples (eleven poppy seeds and three seed mixes).
Considerable amounts were found (1.5–249.0 mg/kg morphine, <0.2 g/kg–45.8 mg/kg codeine,
<2.4 g/kg–136.2 mg/kg thebaine, <0.2 g/kg–27.1 mg/kg papaverine, <0.2 g/kg–108.7 mg/kg
noscapine and <240 g/kg–33.4 mg/kg oripavine), exceeding maximum limits established in some
EU countries and the reference level of morphine in the EU. Furthermore, in some commercial
samples for human consumption, inadequate labelling was found because significant amounts of
alkaloids were detected even though Papaver rhoeas L. seeds were declared on the product label.
Descripción
Citación
Casado-Hidalgo, G.; Pérez-Quintanilla, D.; Morante-Zarcero, S.; Sierra, I. Mesostructured Silica-Coated Magnetic Nanoparticles to Extract Six Opium Alkaloids in Poppy Seeds Prior to Ultra-High-Performance Liquid Chromatography-Tandem Mass Spectrometry Analysis. Foods 2021, 10, 1587. https://doi.org/ 10.3390/foods10071587
Colecciones

Excepto si se señala otra cosa, la licencia del ítem se describe como Atribución 4.0 Internacional